{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:31:35Z","timestamp":1790631095256,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Ascites is a common complication of cirrhosis, and it is associated with increased mortality. The aim of this study was to evaluate the efficacy of long\u2010term albumin administration in decreasing mortality and other complications of patients with cirrhosis and ascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic review was performed using MEDLINE and Embase databases. Randomized controlled trials evaluating long\u2010term albumin administration in patients with cirrhosis and ascites were considered eligible, as long as at least one of the following outcomes was evaluated: mortality, recurrence of ascites\/need for paracentesis, refractory ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, gastrointestinal bleeding, or adverse events. Meta\u2010analysis was performed using the random\u2010effects model, through the Mantel\u2013Haenszel method. The study protocol was registered at PROSPERO platform (CRD42019130078).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search yielded 1517 references. Five randomized controlled trials fulfilled the selection criteria and were included in this meta\u2010analysis, involving 716 individuals. Patients receiving long\u2010term albumin had significantly lower risk of recurrence of ascites\/need for paracentesis when compared with controls (risk ratio\u00a0=\u00a00.56, 95% confidence interval\u00a0=\u00a00.48\u20130.67, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.00001). There was no evidence of significant difference between the long\u2010term albumin and control groups regarding mortality, refractory ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, gastrointestinal bleeding, or adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term albumin administration in patients with cirrhosis and ascites decreases recurrence of ascites\/need for paracentesis. At this point, there is no evidence of significant benefits of long\u2010term albumin administration regarding mortality or other complications of cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15253","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T08:11:48Z","timestamp":1600762308000},"page":"609-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long\u2010term albumin administration in patients with cirrhosis and ascites: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"36","author":[{"given":"Bianca Boff","family":"Sandi","sequence":"first","affiliation":[{"name":"Graduate Program in Medicine: Hepatology Federal University of Health Sciences of Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0295-592X","authenticated-orcid":false,"given":"Gabriel Stefani","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicine: Hepatology Federal University of Health Sciences of Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Alves","family":"de Mattos","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicine: Hepatology Federal University of Health Sciences of Porto Alegre  Porto Alegre Brazil"},{"name":"Gastroenterology and Hepatology Unit Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-0199","authenticated-orcid":false,"given":"\u00c2ngelo Zambam","family":"de Mattos","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicine: Hepatology Federal University of Health Sciences of Porto Alegre  Porto Alegre Brazil"},{"name":"Gastroenterology and Hepatology Unit Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.020"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000480"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20405"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-017-9815-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(62)90895-4"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80194-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i9.1403"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.08.006"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30840-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.150"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2014.245"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00384-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13968"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2178-5"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2012.27.1.13"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0045-2"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12142"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.025"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30948-6"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"S848","DOI":"10.1016\/S0168-8278(15)31495-1","article-title":"Effects of long\u2010term administration of midodrine and albumin in the prevention of complications in patients with cirrhosis on waiting list for liver transplantation. 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