{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:36:35Z","timestamp":1792442195164,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Portal hypertensive gastropathy (PHG) is characterized by noninflammatory edema and vasodilatation of the lamina propria of the mucosal epithelium. In addition, the alterations of intercellular junction proteins and dilatation of the endothelial gaps have been reported. In this study, we examined whether irsogladine maleate (IM), a gastric mucosal protective agent, has the potential to improve PHG by restoration of tight junctions (TJs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four patients with PHG were registered and randomly assigned into two groups: 12 patients in the IM\u2010administration group and 12 patients in the non\u2010administration group. In the administration group, IM (4\u00a0mg\/day) was administered orally for 12\u00a0weeks. Gastric mucosa with a red color in patients with PHG were obtained endoscopically on the registration day and 12\u00a0weeks later. The endoscopic findings were evaluated, an immunohistochemical analysis of claudin\u20103 (a TJ protein) expression in gastric mucosal tissues by a laser microscope was performed, and claudin\u20103 expression was quantified by western blot analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Irsogladine maleate improved the degree of PHG in 2\/12 patients endoscopically, in contrast to none of the 12 patients in the non\u2010administration group. Immunohistochemical analysis showed that expression of claudin\u20103 increased in 8\/12 patients in the IM\u2010administration group and 2\/12 patients in the non\u2010administration group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.036). Western blot analysis revealed that the increase in claudin\u20103 after 12\u00a0weeks was significantly higher in the IM\u2010administration group than in the non\u2010administration group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present pilot study suggested that IM might improve the gastric mucosa in PHG through restoration of TJ\u2010protein claudin\u20103.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15259","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T07:30:53Z","timestamp":1600673453000},"page":"1208-1215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Irsogladine maleate alters expression of a tight junction protein in portal hypertensive gastropathy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1320-6545","authenticated-orcid":false,"given":"Keiji","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Medicine Fukuoka University Nishijin Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Medicine, Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Medicine, Faculty of Medicine Fukuoka 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