{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:12:02Z","timestamp":1790971922127,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Although duodenal cancer is rare, no epidemiological research on this disease has been conducted in Asian countries. We aimed to elucidate the incidence and clinical features of duodenal cancer in Japan using a large\u2010scale national database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data of patients with primary duodenal cancer diagnosed from January 1, 2016, to December 31, 2016, were extracted from the Japanese national cancer registry. Excluding malignant neoplasm of the Vater's ampulla, we calculated the incidence among the population as a crude number of patients with duodenal cancer divided by the total Japanese population in 2016. We performed multivariate analyses using logistic regression models to identify risk factors for advanced cancer, defined as metastatic cancer or local invasion to adjacent organs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data on 3005 patients were included. The incidence of duodenal cancer was 23.7 per 1\u00a0000\u00a0000 person\u2010years. In total, 56.4% of cases were detected at the localized stage. In the localized cancer group, endoscopic resection was more frequently performed (48.0%), whereas in the advanced cancer group, surgery and chemotherapy were the major treatment options (39.3% and 41.5%, respectively). Multivariate analyses identified age \u226580\u00a0years (odds ratio [OR], 1.489; 95% confidence interval [CI], 1.113\u20131.992;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007), incidental detection (OR, 2.325; CI, 1.623\u20133.331;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), and precise examination for symptomatic patients (OR, 10.561; CI, 7.416\u201315.042;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) as independent risk factors for advanced cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study revealed the incidence of duodenal cancer in Japan. However, localized cancer was the major tumor stage at detection, resulting in a high rate of endoscopic resection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15285","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T15:30:12Z","timestamp":1601566212000},"page":"1216-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["The incidence of non\u2010ampullary duodenal cancer in Japan: The first analysis of a national cancer registry"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-0187","authenticated-orcid":false,"given":"Masao","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center  Nagaizumi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-2579","authenticated-orcid":false,"given":"Yohei","family":"Yabuuchi","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center  Nagaizumi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-2099","authenticated-orcid":false,"given":"Naomi","family":"Kakushima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment, Cancer Center Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikitaka","family":"Iguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorimasa","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Showa University Fujigaoka Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Kanetaka","sequence":"additional","affiliation":[{"name":"Department of Surgery Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Uraoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine  Maebashi 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