{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:06:20Z","timestamp":1791216380964,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Screening upper endoscopy can detect esophagogastric (OG) cancers early with improved outcomes. Recent cost\u2010utility studies suggest that opportunistic upper endoscopy at the same setting of colonoscopy might be a useful strategy for screening of OG cancers, and it may be more acceptable to the patients due to cost\u2010saving and convenience. We aim to study the diagnostic performance of this screening strategy in a country with intermediate gastric cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study using a prospective endoscopy database from 2015 to 2017 was performed. Patients included were individuals age &gt;\u00a040 who underwent opportunistic upper endoscopy at the same setting of colonoscopy without any OG symptoms. Neoplastic OG lesions are defined as cancer and high\u2010grade dysplasia. Pre\u2010neoplastic lesions include Barrett's esophagus (BE), intestinal metaplasia (IM), and atrophic gastritis (AG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population involved 1414 patients. Neoplastic OG lesions were detected in five patients (0.35%). Pre\u2010neoplastic lesions were identified in 174 (12.3%) patients. IM was found in 146 (10.3%) patients with 21 (1.4%) having extensive IM. The number needed to scope to detect a neoplastic OG lesion is 282.8 with an estimated cost of USD$141\u00a0400 per lesion detected. On multivariate regression, age \u2265\u00a060 (RR: 1.84, 95% CI: 1.29\u20132.63) and first\u2010degree relatives with gastric cancer (RR: 1.64, 95% CI: 1.06\u20132.55) were independent risk factors for neoplastic or pre\u2010neoplastic OG lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For countries with intermediate gastric cancer risk, opportunistic upper endoscopy may be an alternative screening strategy in a selected patient population. Prospective trials are warranted to validate its performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15290","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T09:38:33Z","timestamp":1602322713000},"page":"1081-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Opportunistic upper endoscopy during colonoscopy as a screening strategy for countries with intermediate gastric cancer risk"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-6338","authenticated-orcid":false,"given":"Joel Wen Liang","family":"Lau","sequence":"first","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Junn Wei","family":"Khoo","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue Hao","family":"Leong","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian Zhi","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Surgery National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-6478","authenticated-orcid":false,"given":"Asim","family":"Shabbir","sequence":"additional","affiliation":[{"name":"Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-4606","authenticated-orcid":false,"given":"Khay Guan","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1756-3737","authenticated-orcid":false,"given":"Calvin Jianyi","family":"Koh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9772-7905","authenticated-orcid":false,"given":"Jimmy Bok Yan","family":"So","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Division of General Surgery (Upper Gastrointestinal Surgery), Department of Surgery National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70072-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i28.5086"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640617722902"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.05.001"},{"key":"e_1_2_5_7_1","unstructured":"LingA FooL LeeE SiminK XiaojiaG LimSet al.Singapore Cancer Registry 50th Anniversary Monograph (1968\u20132017) [Internet].www.nrdo.gov.sg.2020[cited 5 March 2020]. Available from:https:\/\/www.nrdo.gov.sg\/docs\/librariesprovider3\/default-document-library\/thespore-cancerregistry_commerativebook_-1.pdf?sfvrsn=231fce6e_0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.608"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i5.736"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.09.013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01671151"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.026"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.04.063"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.228874"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.10.039"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70441-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050041"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28065"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15607"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.071"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0859-1883"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-318126"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04956.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314498"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15290","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.15290","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:11:09Z","timestamp":1693361469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.15290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/jgh.15290"],"URL":"https:\/\/doi.org\/10.1111\/jgh.15290","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,30]]},"assertion":[{"value":"2020-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}