{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:15:27Z","timestamp":1791504927621,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Due to the increasing resistance of <jats:italic>Helicobacter pylori<\/jats:italic>, there is a need for novel antibiotic treatment protocols. We aimed to perform a systematic review and meta\u2010analysis in order to determine the effectiveness and safety of rifabutin triple therapy for <jats:italic>H.\u00a0pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic review of prospective clinical trials with a treatment arm consisting of proton pump inhibitor, amoxicillin, and rifabutin and a meta\u2010analysis of randomized controlled trials (RCTs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010three prospective studies including 44 datasets were identified. Meta\u2010analysis of four RCTs for rescue treatment found no difference between treatment groups (odds ratio [OR] 0.88, 95% confidence interval [CI] 0.437\u20131.791, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a068.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.733). Only one RCT compared rifabutin therapy with control for first\u2010line treatment of <jats:italic>H.\u00a0pylori<\/jats:italic> infection (OR 3.78, 95% CI 2.44\u20135.87, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Treatment was more likely to be successful in Asian <jats:italic>versus<\/jats:italic> non\u2010Asian populations (81.0% <jats:italic>vs<\/jats:italic> 72.4%, <jats:italic>P\u00a0=<\/jats:italic>\u00a00.001) and when daily amoxicillin dose was \u2265\u00a03000\u00a0mg or proton pump inhibitor dose was \u2265\u00a080\u00a0mg or treatment duration was 14\u00a0days (80.6% <jats:italic>vs<\/jats:italic> 66.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). The overall event rate for adverse effects was 24.8% (729\/2937) (95% CI 0.23\u20130.26), and the pooled OR for adverse effects in the treatment <jats:italic>versus<\/jats:italic> control group was 0.93 (95% CI 0.50\u20131.75) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a079.76, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.82).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Evidence for the effectiveness of rifabutin for the first\u2010line treatment of <jats:italic>H.\u00a0pylori<\/jats:italic> infection in adults is limited, and studies comparing rifabutin with conventional first\u2010line treatments are lacking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15294","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T09:38:14Z","timestamp":1602322694000},"page":"1392-1402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Rifabutin triple therapy for first\u2010line and rescue treatment of <i>Helicobacter pylori<\/i> infection: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"given":"Rachel","family":"Gingold\u2010Belfer","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center, and the Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Niv","sequence":"additional","affiliation":[{"name":"Division of Patient Safety and Quality Improvement Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Levi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center, and the Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-613X","authenticated-orcid":false,"given":"Doron","family":"Boltin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Rabin Medical Center, and the Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-320839"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.11.020"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw024"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05437-11"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.6.1497"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm039"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01900.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000191204"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12089"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.234.qrth"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12296"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/415648"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.007"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(14)60045-1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ygh2.372"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1266"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-3734"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12557"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8020199"},{"key":"e_1_2_5_25_1","first-page":"198","article-title":"Seven\u2010day genotypic resistance\u2010guided triple Helicobacter pylori eradication therapy can be highly effective","volume":"31","author":"Papastergiou V","year":"2018","journal-title":"Ann. 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