{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T21:59:32Z","timestamp":1775944772269,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600510"],"award-info":[{"award-number":["81600510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastroesophageal varices (GEV) present in compensated advanced chronic liver disease (cACLD) and can develop into high\u2010risk varices (HRV). The gold standard for diagnosing GEV is esophagogastroduodenoscopy (EGD). However, EGD is invasive and less tolerant. This study aimed to develop and validate radiomics signatures based on noncontrast\u2010enhanced computed tomography (CT) images for non\u2010invasive diagnosis of GEV and HRV in patients with cACLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The multicenter trial enrolled 161 patients with cACLD from six university hospitals in China between January 2015 and September 2019, who underwent both EGD and noncontrast\u2010enhanced CT examination within 14\u00a0days prior to the endoscopy. Two radiomics signatures, termed <jats:italic>r<\/jats:italic>GEV and <jats:italic>r<\/jats:italic>HRV, respectively, were built based on CT images in a training cohort of 129 patients and validated in a prospective validation cohort of 32 patients (ClinicalTrials. gov identifier: NCT03749954).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the training cohort, both <jats:italic>r<\/jats:italic>GEV and <jats:italic>r<\/jats:italic>HRV exhibited high discriminative abilities on determining the existence of GEV and HRV with the area under receiver operating characteristic curve (AUC) of 0.941 (95% confidence interval [CI] 0.904\u20130.978) and 0.836 (95% CI 0.766\u20130.905), respectively. In validation cohort, <jats:italic>r<\/jats:italic>GEV and <jats:italic>r<\/jats:italic>HRV showed high discriminative abilities with AUCs of 0.871 (95% CI 0.739\u20131.000) and 0.831 (95% CI 0.685\u20130.978), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that <jats:italic>r<\/jats:italic>GEV and <jats:italic>r<\/jats:italic>HRV could serve as the satisfying auxiliary parameters for detection of GEV and HRV with good diagnostic performance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15306","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T18:04:59Z","timestamp":1603130699000},"page":"1562-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Development and validation of a radiomics signature as a non\u2010invasive complementary predictor of gastroesophageal varices and high\u2010risk varices in compensated advanced chronic liver disease: A multicenter study"],"prefix":"10.1111","volume":"36","author":[{"given":"Yifei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Zhujiang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-1177","authenticated-orcid":false,"given":"Fangze","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Zhujiang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-8281","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Digestive Disease Institute Shanghai Tongji Hospital, Tongji University School of Medicine  Shanghai 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