{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:53:58Z","timestamp":1762642438674,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>It has been reported that serum quantification of anti\u2010HBc (qAnti\u2010HBc) could predict antiviral response in chronic hepatitis B (CHB) patients, while its role in hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF) remains unclear. Its implication in HBV\u2010ACLF was evaluated in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline serum qAnti\u2010HBc levels were retrospectively detected in HBV\u2010ACLF and CHB patients using recently developed double\u2010sandwich immunoassay. The association of qAnti\u2010HBc level with clinical outcomes was evaluated by multiple logistic regression. Nomogram was adopted to formulate an algorithm incorporating qAnti\u2010HBc for the prediction of survival in HBV\u2010ACLF. The post\u2010hospitalization of HBV\u2010ACLF patients were followed\u2010up for 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010eight HBV\u2010ACLF as training set, 80 HBV\u2010ACLF as validation set and 216 CHB cases were included. Serum qAnti\u2010HBc level was significantly higher in HBV\u2010ACLF (4.95\u00a0\u00b1\u00a00.54\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/mL) than CHB patients (4.47\u00a0\u00b1\u00a00.84\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/mL) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Among HBV\u2010ACLF cases, both in training and validation set, patients with poor outcomes had lower qAnti\u2010HBc level. Area under receiver operating characteristic curve of the novel qAnti\u2010HBc inclusive model was 0.82, superior to 0.73 from model for end\u2010stage liver disease scores (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018), which was confirmed in validation set. During follow\u2010up, the qAnti\u2010HBc level declined at month 3 and month 6, then plateaued at 3.84\u00a0log<jats:sub>10<\/jats:sub>\u00a0IU\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum qAnti\u2010HBc level was associated with disease severity and might be served as a novel biomarker in the prediction of HBV\u2010ACLF clinical outcomes. The underlying immunological mechanism warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15310","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T17:43:56Z","timestamp":1603388636000},"page":"1291-1299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic value of anti\u2010HBc quantification in hepatitis B virus related acute\u2010on\u2010chronic liver failure"],"prefix":"10.1111","volume":"36","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi\u2010ming","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital Shanghai Jiao Tong 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De\u2010min","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Sino\u2010French Research Centre for Life Sciences and Genomics Ruijin Hospital, Shanghai Jiao Tong 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