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Several reports have described the gastrointestinal (GI) manifestations in the infected patients. The systematic review was designed to highlight the gaps in our knowledge about the prevalence and clinical significance of GI symptoms in patients with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed database and Google articles published in both English and Chinese up to June 3, 2020, using search terms \u201cclinical features,\u201d \u201c2019 novel coronavirus,\u201d \u201c2019\u2010nCoV,\u201d \u201cCOVID\u201019,\u201d or \u201cSARS\u2010Cov\u20102.\u201d Observational studies, case reports, or letters describing the clinical features or observational studies regarding the detection and\/or isolation of severe acute respiratory syndrome coronavirus 2 viruses in stools were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 22 publications were finally selected. It was reported that GI symptoms occurred in about 3\u201340.7% of patients. GI manifestations included nausea, diarrhea, anorexia, vomiting, abdominal pain, belching, abdominal distension, and GI hemorrhage. Diarrhea was the most common GI symptom. Infected patients had various degrees of liver dysfunction, and the severity of liver dysfunction was significantly associated with the severity of the disease. Therapy focusing on digestive system like liver supportive therapy or nutrition support or probiotics has been demonstrated to be effective interventions, which greatly improve prognosis. Fecal\u2013oral transmission route is a potential risk for transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GI symptoms are common in COVID\u201019. Strengthening the recognition on abnormalities in digestive system of patients with COVID\u201019 is crucial for early identification and timely treatment, especially for those atypical patients. Hygiene protection and keeping the drainpipe free flowing are necessary for everyone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15323","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T12:25:30Z","timestamp":1604579130000},"page":"1414-1422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Digestive system manifestations and clinical significance of coronavirus disease 2019: A systematic literature review"],"prefix":"10.1111","volume":"36","author":[{"given":"Lei","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianming","family":"Liao","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine Union Hospital of Fujian Medical University  Fuzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-5083","authenticated-orcid":false,"given":"Fangyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Jinling Hospital Medical School of Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25681"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-020-00153-x"},{"key":"e_1_2_5_4_1","unstructured":"GuanW NiZ HuY et al.Clinical characteristics of 2019 novel coronavirus infection in China. medRxiv 2020."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200274"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m606"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14238"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30079-5"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","unstructured":"AnP ChenH JiangX et al.Clinical features of 2019 novel coronavirus pneumonia presented gastrointestinal symptoms but without fever onset. 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