{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:24:14Z","timestamp":1784366654411,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Real\u2010world data on sofosbuvir\/velpatasvir with and without ribavirin (SOF\/VEL\u00a0\u00b1\u00a0RBV), particularly among patients with genotype 3 (GT3) decompensated cirrhosis, prior treatment, coinfection, and hepatocellular carcinoma (HCC), are scarce. We aimed to assess the efficacy and safety of SOF\/VEL\u00a0\u00b1\u00a0RBV in a real\u2010world setting that included both community and incarcerated GT3 hepatitis C virus (HCV) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all GT3 HCV patients treated with SOF\/VEL\u00a0\u00b1\u00a0RBV in our institution. The primary outcome measure was the overall sustained virological response 12\u00a0weeks after treatment (SVR12), reported in both intention\u2010to\u2010treat (ITT) and per\u2010protocol analyses. The secondary outcome measures were SVR12 stratified by the presence of decompensated cirrhosis, prior treatment, HCC, and HIV\/hepatitis C virus coinfection and the occurrence rate of serious adverse events requiring treatment cessation or hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 779 HCV patients were treated with 12\u00a0weeks of SOF\/VEL\u00a0\u00b1\u00a0RBV, of which 85% were treated during incarceration. Among the 530 GT3 HCV patients, 31% had liver cirrhosis, and 6% were treatment\u2010experienced. The overall SVR12 for GT3 was 98.7% (95% confidence interval: 97.3%, 99.5%) and 99.2% (95% confidence interval: 98.1%, 99.8%) in ITT and per\u2010protocol analyses, respectively. High SVR12 was also seen in ITT analysis among GT3 HCV patients with decompensated cirrhosis (88%), prior treatment (100%), HCC (100%), and HIV\/hepatitis B virus coinfection (100%). Apart from one patient who developed myositis, no other serious adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The SOF\/VEL\u00a0\u00b1\u00a0RBV is a safe and efficacious treatment option for GT3 HCV patients in a real\u2010world setting. SOF\/VEL with RBV may be considered for decompensated GT3 HCV patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15324","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T04:39:30Z","timestamp":1605933570000},"page":"1300-1308","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy and safety of sofosbuvir\/velpatasvir in a real\u2010world chronic hepatitis C genotype 3 cohort"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-1183","authenticated-orcid":false,"given":"Yu Jun","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem Harichander","family":"Thurairajah","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Division of Gastroenterology and Hepatology National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong Ming","family":"Fock","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngai Moh","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiquan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kwek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Bin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng Cong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loshini Senthil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng Kiong","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8549","authenticated-orcid":false,"given":"Tiing\u2010Leong","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO.Global hepatitis report 2017. 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