{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:58:08Z","timestamp":1789793888448,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"Abstract<\/jats:title>Background and Aims<\/jats:title>The revolution of the antiviral treatment of hepatitis C virus (HCV) infection resulting in higher effectiveness came with the introduction of direct\u2010acting antivirals with pangenotypic regimens as a final touch. Among them, the combination of glecaprevir (GLE) and pibrentasvir (PIB) provides the opportunity for shortening therapy to 8\u00a0weeks in the majority of patients. Because of still insufficient evaluation of this regimen in the real\u2010world experience, our study aimed to assess the efficacy and safety of 8\u2010week GLE\/PIB in chronic hepatitis C patients depending on liver fibrosis and genotype (GT).<\/jats:p><\/jats:sec>Methods<\/jats:title>The analysis included patients who received GLE\/PIB for 8\u00a0weeks selected from the EpiTer\u20102 database, large retrospective national real\u2010world study evaluating antiviral treatment in 12\u00a0584 individuals in 22 Polish hepatology centers.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 1034 patients with female predominance (52%) were enrolled in the analysis. The majority of them were treatment na\u00efve (94%), presented liver fibrosis (F) of F0\u2013F3 (92%), with the most common GT1b, followed by GT3. The overall sustained virologic response after exclusion of nonvirologic failures was achieved in 95.8% and 98%, respectively (P<\/jats:italic>\u00a0=\u00a00.19). In multivariate logistic regression HCV GT\u20103 (beta\u00a0=\u00a00.07, P<\/jats:italic>\u00a0=\u00a00.02) and HIV infection (beta\u00a0=\u00a0\u22120.14, P<\/jats:italic>\u00a0<\u00a00.001) were independent predictors of nonresponse.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We demonstrated high effectiveness of 8\u2010week GLE\/PIB treatment in a non\u2010GT3 population irrespective of liver fibrosis stage. Comparable efficacy was achieved in non\u2010cirrhotic patients regardless of the genotype, including GT3 HCV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15337","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T01:04:06Z","timestamp":1605056646000},"page":"1944-1952","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Is an 8\u2010week regimen of glecaprevir\/pibrentasvir sufficient for all hepatitis C virus infected patients in the real\u2010world experience?"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-1084","authenticated-orcid":false,"given":"Dorota","family":"Zar\u0119bska\u2010Michaluk","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Voivodeship Hospital, Jan Kochanowski University Kielce 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