{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:20Z","timestamp":1790517380489,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Functional gastrointestinal disorders are a group of stress\u2010sensitive gut\u2013brain disorders. The COVID\u201019 outbreak has caused immense stress and anxiety among the general public. Strict measures to counter COVID\u201019 emergency, including physical distancing, have also taken a toll on physical and mental health. We investigated the impact of the COVID\u201019 pandemic on the gastrointestinal and psychological symptoms of functional dyspepsia (FD) and irritable bowel syndrome (IBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An online survey was conducted in Japan for a group of randomly assigned panelists from May 26 to 27, 2020. Each respondent answered a questionnaire on stress, physical distancing, and worries about COVID\u201019. Gastrointestinal symptoms were assessed to diagnose FD and IBS (Rome III), and psychological symptoms were assessed using the Hospital Anxiety and Depression Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5157 subjects were finally enrolled, with FD in 8.5%, IBS in 16.6%, and FD\u2013IBS overlap in 4.0%. For both gastrointestinal and psychological symptoms, respondents with FD\u2013IBS overlap showed the worst scores, followed by IBS\u2010alone, then FD\u2010alone respondents. During the COVID\u201019 pandemic, 11.9% of respondents reported deterioration and 2.8% reported improvement of gastrointestinal symptoms. FD\u2013IBS overlap, psychological disease comorbidity, and stress at work\/school were significantly associated with symptom deterioration. Younger age, commuting by public transport, and work\/study from home were associated with symptom improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The COVID\u201019 pandemic negatively affected FD\/IBS subjects, with respondents showing FD\u2013IBS overlap syndrome as the most important independent factor associated with deterioration in gastrointestinal symptoms. Physicians need to take extra care of FD\/IBS patients in the post\u2010COVID period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15346","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T17:16:37Z","timestamp":1605546997000},"page":"1820-1827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Impacts of the COVID\u201019 pandemic on functional dyspepsia and irritable bowel syndrome: A population\u2010based survey"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6949-932X","authenticated-orcid":false,"given":"Tadayuki","family":"Oshima","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewin Tien Ho","family":"Siah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Miura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Tomita","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Fukui","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-642X","authenticated-orcid":false,"given":"Hiroto","family":"Miwa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine Hyogo College of Medicine  Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14165"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-10-199511150-00007"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1014-3"},{"key":"e_1_2_5_6_1","unstructured":"2020.World Health Organization.WHO Director\u2010General's opening remarks at the media briefing on COVID\u201019\u201011 March 2020 [Internet]. 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