{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:33:08Z","timestamp":1790249588206,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The FibroScan\u2013aspartate aminotransferase (FAST) score was developed for identifying patients with non\u2010alcoholic steatohepatitis, who also have an elevated non\u2010alcoholic fatty liver disease (NAFLD) activity score (NAS)\u00a0\u2265\u00a04 and significant fibrosis (F\u00a0\u2265\u00a02). We aimed to validate it in our NAFLD cohort and assess if it correlates with the histological changes after bariatric surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with NAFLD, including those undergoing bariatric surgery, were included. The FAST score was calculated using liver stiffness measure, controlled attenuation parameter, and aspartate aminotransferase. Calibration and discrimination of the model were assessed by calibration plots and area under the receiver operating characteristic curve, respectively. Sensitivity and specificity were assessed at the rule\u2010out and rule\u2010in cutoffs (\u22640.35 and \u22650.67), respectively. Changes in the NAS and FAST scores were compared in the bariatric cohort 1\u00a0year after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort composed of 309 patients, of which 48 patients underwent repeat liver biopsy at 1\u00a0year. The model showed good discrimination with area under the receiver operating characteristic curve of 0.79 (0.74\u20130.84); however, it was not satisfactorily calibrated (Hosmer\u2013Lemeshow test, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). The sensitivity and specificity at the rule\u2010out and rule\u2010in cutoffs were 0.90 and 0.84, respectively. A significant correlation was seen between the 1\u2010year reduction in the NAS and FAST scores (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.38, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). A significant reduction in the median FAST score was seen in patients who had \u22652\u2010point reduction in NAS after bariatric surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FibroScan\u2013aspartate aminotransferase score demonstrated good discrimination for fibrotic non\u2010alcoholic steatohepatitis in our cohort. However, a miscalibration resulted in overprediction. The score correlated well with the histological response to interventions for NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15358","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T05:41:52Z","timestamp":1606282912000},"page":"1309-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["FibroScan\u2013aspartate aminotransferase score in an Asian cohort of non\u2010alcoholic fatty liver disease and its utility in predicting histological resolution with bariatric surgery"],"prefix":"10.1111","volume":"36","author":[{"given":"Abhinav","family":"Anand","sequence":"first","affiliation":[{"name":"Department of Gastroenterology All India Institute of Medical Sciences, New Delhi  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Elhence","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology All India 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