{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:48:16Z","timestamp":1782974896667,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Patients with functional dyspepsia (FD) often have concomitant anxiety and depression. Mindfulness\u2010based cognitive therapy (MBCT) combines the principles of cognitive behavioral therapy and mindfulness. It is a group\u2010based therapy and has been shown to be efficacious in functional gastrointestinal disorders. There are no randomized controlled trials (RCTs) evaluating MBCT in FD. We aimed to evaluate feasibility and efficacy of MBCT in FD management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a mixed\u2010method single\u2010center pilot randomized trial of 28 patients fulfilling ROME\u2010III criteria for FD. Fifteen patients were randomized to an 8\u2010week MBCT program while 13 underwent treatment\u2010as\u2010usual (TAU). Patients completed questionnaires at baseline and at week 8. Two focus\u2010groups were conducted. Feasibility of recruitment, acceptability of randomization, procedures and intervention, handout compliance and feasibility of quantitative measures were assessed. The primary outcome was subjective\u2010clinical\u2010assessment of FD symptoms (SCA\u2010FD). Secondary outcome measures included Short\u2010form Nepean Dyspepsia Index (SF\u2010NDI), subjective\u2010clinical\u2010assessment of general health (SCA\u2010GH), EuroQoL\u2010Visual Analog Scale (EuroQoL\u2010VAS), and Depression, Anxiety and Stress Scale\u201321 Items (DASS\u201021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve of 15 patients in the MBCT group completed the program. There was a trend towards symptom improvement, with 90% in the MBCT group reporting improvement in SCA\u2010FD compared with 45% in TAU(<jats:italic>P<\/jats:italic>\u00a0=\u00a00.063). Patients who underwent MBCT reported greater improvement in SF\u2010NDI (mean change: \u22128.8 (SD: 7.5) <jats:italic>vs<\/jats:italic> \u22120.7 (7.2), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) and DASS\u201021 (\u221219.8 (29.5) <jats:italic>vs<\/jats:italic> \u22125.5 (6.6) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.13) compared with TAU. There was no difference in SCA\u2010GH and EuroQoL\u2010VAS. Based on SCA\u2010FD improvement, the eventual RCT will require 50 patients (25 in each group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mindfulness\u2010based cognitive therapy is likely efficacious for FD, and it would be feasible to conduct a RCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15389","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T04:14:13Z","timestamp":1609301653000},"page":"2058-2066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mindfulness\u2010based cognitive therapy in functional dyspepsia: A pilot randomized trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8832-9561","authenticated-orcid":false,"given":"Kevin Kim\u2010Jun","family":"Teh","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Kang","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of General Medicine Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinjal","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Psychology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Wen","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hao","sequence":"additional","affiliation":[{"name":"Health Services Research Centre Singapore Health Services  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lui\u2010Yee","family":"Ang","sequence":"additional","affiliation":[{"name":"Behavioral Medicine Unit Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Lew\u2010Yuen","family":"Foong","sequence":"additional","affiliation":[{"name":"Behavioral Medicine Unit Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-2038","authenticated-orcid":false,"given":"Andrew Ming\u2010Liang","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-5101","authenticated-orcid":false,"given":"Kewin Tien\u2010Ho","family":"Siah","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Department of Medicine National University Hospital  Singapore"},{"name":"Department of Medicine, Yong Loo Lin School of Medicine The National University of Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8884-3381","authenticated-orcid":false,"given":"Webber Pak\u2010Wo","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai\u2010Choung","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Joseph","family":"Mesenas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Hooi","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tien","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.039"},{"key":"e_1_2_7_4_1","first-page":"251","article-title":"Fear, panic, anxiety, and disorders of emotion","volume":"43","author":"Barlow DH","year":"1996","journal-title":"Neb. 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