{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:21:11Z","timestamp":1785252071277,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Whether <jats:italic>Helicobacter pylori<\/jats:italic> eradication prevents metachronous recurrence after endoscopic resection (ER) of early gastric cancer remains controversial. This multicenter retrospective study aimed to evaluate the long\u2010term (&gt;\u00a05\u00a0years) effects of <jats:italic>H.\u00a0pylori<\/jats:italic> eradication by stratifying patients' baseline degrees of atrophic gastritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 483 <jats:italic>H.\u00a0pylori<\/jats:italic>\u2010positive patients who had undergone ER for early gastric cancer were divided into two groups\u2014(i) those having undergone successful <jats:italic>H.\u00a0pylori<\/jats:italic> eradication within 1\u00a0year after ER (eradicated group, <jats:italic>n<\/jats:italic>\u00a0=\u00a0294) and (ii) those with failed or not attempted <jats:italic>H.\u00a0pylori<\/jats:italic> eradication (non\u2010eradicated group, <jats:italic>n<\/jats:italic>\u00a0=\u00a0189). The cumulative incidences of metachronous gastric cancer between the two groups were compared for all patients, for patients with mild\u2010to\u2010moderate atrophic gastritis (<jats:italic>n<\/jats:italic>\u00a0=\u00a0182), and for patients with severe atrophic gastritis (<jats:italic>n<\/jats:italic>\u00a0=\u00a0301).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 5.2\u00a0years (range 1.1\u201314.8), metachronous cancer developed in 52 (17.7%) patients in the eradicated group and in 35 (18.5%) patients in the non\u2010eradicated group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.11, log\u2013rank test). In patients with mild\u2010to\u2010moderate atrophic gastritis (111 and 71 in the eradicated and non\u2010eradicated groups, respectively), the cumulative incidence of metachronous cancer was significantly lower in the eradicated group than that in the non\u2010eradicated group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03, log\u2013rank test). However, no significant intergroup difference was observed in patients with severe atrophic gastritis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.69, log\u2013rank test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> eradication had a preventive effect on the development of metachronous gastric cancer in patients with mild\u2010to\u2010moderate atrophic gastritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15396","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T02:09:43Z","timestamp":1609985383000},"page":"2083-2090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["<i>Helicobacter pylori<\/i> eradication prevents secondary gastric cancer in patients with mild\u2010to\u2010moderate atrophic gastritis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-6282","authenticated-orcid":false,"given":"Minoru","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-9003","authenticated-orcid":false,"given":"Tsutomu","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toyonaka Municipal Hospital  Toyonaka 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