{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:14:30Z","timestamp":1791454470887,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet improves irritable bowel syndrome (IBS) symptoms. Data on long\u2010term \u201cmodified\u201d FODMAP diet are emerging. We aimed to assess efficacy and acceptability of short\u2010term \u201cstrict\u201d low FODMAP diet (LFD) and long\u2010term \u201cmodified\u201d FODMAP diet in patients with diarrhea\u2010predominant IBS (IBS\u2010D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective randomized trial included patients with IBS\u2010D (Rome IV) and IBS severity scoring system (IBS\u2010SSS)\u00a0\u2265\u00a0175. In phase I (4\u00a0weeks), patients were randomized to strict LFD and traditional dietary advice (TDA) groups. From 4 to 16\u00a0weeks, LFD group was advised systematic reintroduction of FODMAPs (\u201cmodified\u201d FODMAP diet). Response was defined as &gt;\u00a050\u2010point reduction in IBS\u2010SSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the total 166 patients with IBS\u2010D screened, 101 (mean age 41.9\u00a0\u00b1\u00a017.1\u00a0years, 58% male) were randomized to LFD (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a052) and TDA (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a049) groups. Both at 4 and 16\u00a0weeks, total IBS\u2010SSS and IBS quality of life score reduced significantly in both groups, but there was significantly greater reduction in LFD group. By intention\u2010to\u2010treat analysis, responders in LFD group were significantly higher than TDA group (4\u00a0weeks\u201462.7% [32\/51]\n                      <jats:italic>vs<\/jats:italic>\n                      40.8% [20\/49], respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0448; 16\u00a0weeks\u201452.9% [27\/51]\n                      <jats:italic>vs<\/jats:italic>\n                      30.6% [15\/49], respectively;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0274). Compliance to LFD was 93% at 4\u00a0weeks and 64% at 16\u00a0weeks. Energy, carbohydrate, fat, and fiber intake showed reduction in LFD group at 4\u00a0weeks, which improved till 16\u00a0weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Strict LFD for short\u2010term and \u201cmodified\u201d LFD for long term in IBS\u2010D patients is acceptable and leads to significant improvement in symptoms and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15410","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T10:04:06Z","timestamp":1611050646000},"page":"2107-2115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["Low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet in patients with diarrhea\u2010predominant irritable bowel syndrome: A prospective, randomized trial"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6347-0988","authenticated-orcid":false,"given":"Omesh","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaveta","family":"Batta","sequence":"additional","affiliation":[{"name":"Department of Dietetics Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Nohria","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Kishore","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medicine Baba Jaswant Singh Dental College Hospital and Research Institute  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College and Hospital  Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.031"},{"key":"e_1_2_7_3_1","first-page":"22","article-title":"Epidemiological and clinical profile of irritable bowel syndrome in India: report of the Indian Society of Gastroenterology Task Force","volume":"27","author":"Ghoshal UC","year":"2008","journal-title":"Indian J. 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