{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:30:19Z","timestamp":1747186219971,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Acute variceal bleeding (AVB) is a fatal adverse event of cirrhosis, and endoscopic band ligation (EBL) is the standard treatment for AVB. We developed a novel bedside risk\u2010scoring model to predict the 6\u2010week mortality in cirrhotic patients undergoing EBL for AVB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cox regression analysis was used to assess the relationship of clinical, biological, and endoscopic variables with the 6\u2010week mortality risk after EBL in a derivation cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a01373). The primary outcome was the predictive accuracy of the new model for the 6\u2010week mortality in the validation cohort. Moreover, we tested the adequacy of the mortality risk\u2010based stratification and the discriminative performance of our new model in comparison with the Child\u2013Turcotte\u2013Pugh (CTP) and the model for end\u2010stage liver disease scores in the validation cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0200).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On multivariate Cox regression analysis, five objective variables (use of beta\u2010blockers, hepatocellular carcinoma, CTP class C, hypovolemic shock at initial presentation, and history of hepatic encephalopathy) were scored to generate a 12\u2010point risk\u2010prediction model. The model stratified the 6\u2010week mortality risk in patients as low (3.5%), intermediate (21.1%), and high (53.4%) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Time\u2010dependent area under the receiver operating characteristic curve for 6\u2010week mortality showed that this model was a better prognostic indicator than the CTP class alone in the derivation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and validation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A simplified scoring model with high potential for generalization refines the prediction of 6\u2010week mortality in high\u2010risk cirrhotic patients, thereby aiding the targeting and individualization of treatment strategies for decreasing the mortality rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15426","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T04:27:27Z","timestamp":1612585647000},"page":"1935-1943","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Bedside risk\u2010scoring model for predicting 6\u2010week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-6166","authenticated-orcid":false,"given":"Jung Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine  Hwaseong South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-7468","authenticated-orcid":false,"given":"Se Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine  Hwaseong South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang Han","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine  Hwaseong South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Hae","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine  Hwaseong South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Seok","family":"Bang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine  Chuncheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-3481","authenticated-orcid":false,"given":"Chan Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hanyang University Guri Hospital, Hanyang University College of Medicine  Guri South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Won","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hallym University Sacred Heart Hospital, Hallym University College of Medicine  Anyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Gun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine  Seoul South 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