{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:33:37Z","timestamp":1784291617926,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>No inception cohort study has ever evaluated the early course of moderate\u2010to\u2010severe ulcerative colitis (UC) within 1\u00a0year of diagnosis in the non\u2010Caucasian population. We aimed to investigate the early clinical course of moderate\u2010to\u2010severe UC patients in terms of remission, relapse, UC\u2010related hospitalizations, colectomy, mortality, and overall use of medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the MOSAIK inception cohort, which is an ongoing multicenter, prospective, hospital\u2010based, observational cohort, 354 patients with moderate\u2010to\u2010severe UC were followed up for 1\u00a0year. Main outcomes of UC and predictive factors for medication use over the course of 1\u00a0year were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Among 354 patients, 276 (78.0%) patients were followed up for 1\u00a0year. The rates of remission, relapse, UC\u2010related hospitalizations, and proximal disease extension were 95.3%, 39.6%, 15.2%, and 12.3%, respectively. Systemic corticosteroids, thiopurines, and biologics were administered to 61.2%, 30.4%, and 10.5% of patients, respectively, throughout 1\u00a0year. One year after, 58.2% patients experienced remission or mild endoscopic activity. Overall disease courses did not show much difference according to moderate or severe disease activity at baseline. In addition, no colectomy and mortality were observed for 1\u00a0year. Predictive factors for medication use included disease severity, disease extent, endoscopic severity, and presence of periappendiceal inflammation at baseline for corticosteroid, disease extent and initial corticosteroid use for thiopurine, and only initial corticosteroid use for biologics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Korean patients with moderate\u2010to\u2010severe UC may have more favorable early outcomes than Western patients. However, outcomes of them need to be further looked into for a longer time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15435","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T23:23:55Z","timestamp":1612826635000},"page":"2149-2156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early course of newly diagnosed moderate\u2010to\u2010severe ulcerative colitis in Korea: Results from a hospital\u2010based inception cohort study (MOSAIK)"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-0443","authenticated-orcid":false,"given":"Jin Young","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9403-230X","authenticated-orcid":false,"given":"Jae Myung","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-3825","authenticated-orcid":false,"given":"Chang Kyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7870-3003","authenticated-orcid":false,"given":"Young Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eulji University School of Medicine, Eulji Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3746-8419","authenticated-orcid":false,"given":"Kyu Chan","family":"Huh","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Konyang University Hospital, Konyang University College of Medicine  Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-3967","authenticated-orcid":false,"given":"Jeong Eun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dankook University College of Medicine  Cheonan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-3458","authenticated-orcid":false,"given":"You Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul Paik Hospital, Inje University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6533-9644","authenticated-orcid":false,"given":"Chang Soo","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital  Guri South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3885-6763","authenticated-orcid":false,"given":"Soon Man","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungbuk National University Hospital, Chungbuk National University College of Medicine  Cheongju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2282-8904","authenticated-orcid":false,"given":"Jae Hee","family":"Cheon","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Institute of Gastroenterology, Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1893-7726","authenticated-orcid":false,"given":"Young Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University, College of Medicine, Seoul National University Bundang Hospital  Seongnam\u2010si South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6647-6325","authenticated-orcid":false,"given":"Byong Duk","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6740-0613","authenticated-orcid":false,"given":"YoungJa","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinical Research Team, Medical Affairs Janssen Korea Ltd.  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