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Using a large database, we sought to describe the epidemiology of several psychiatric disorders in CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried a multicenter database (Explorys Inc), an aggregate of electronic health record data from 26 major integrated healthcare systems from 2016 to 2020 consisting of 360 hospitals in the USA. A cohort of patients with a Systematized Nomenclature Of Medicine \u2013 Clinical Terms diagnosis of CD was identified. Multivariate analysis was performed using Statistical Package for Social Sciences version 25.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 37\u00a0465\u00a0810 patients in the database between 2016 and 2020, there were 112\u00a0340 (0.30%) individuals with CD. When compared with patients with no history of CD, patients with CD were more likely to have a history of anxiety (odds ratio [OR]: 1.385; 95% confidence interval [CI]: 1.364\u20131.407), depression (OR: 1.918; 95% CI: 1.888\u20131.947), bipolar (OR: 1.321; 95% CI: 1.289\u20131.354), attention\u2010deficit hyperactivity disorder (OR: 1.753; 95% CI: 1.714\u20131.792), eating disorder (OR: 15.84; 95% CI: 15.533\u201316.154), and childhood autistic disorder (OR: 4.858; 95% CI: 3.626\u20136.508). Patients with CD and psychiatric conditions were more likely to be smokers, with history of alcohol and substance abuse as well as a history of personality disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large database, patients with CD are at increased risk of having multiple psychiatric diseases including anxiety, depression, bipolar, attention\u2010deficit hyperactivity disorder, eating disorder, and childhood autism. Individual care and referral to psychiatry when appropriate are warranted while taking care of this group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15437","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T11:02:20Z","timestamp":1612782140000},"page":"2165-2170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Epidemiology and risk of psychiatric disorders among patients with celiac disease: A population\u2010based national study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-8705","authenticated-orcid":false,"given":"Motasem","family":"Alkhayyat","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thabet","family":"Qapaja","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manik","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Almomani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Abureesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Staten Island University Hospital  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omaymah","family":"Al\u2010otoom","sequence":"additional","affiliation":[{"name":"University of Jordan Medical School, University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Zmaili","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad","family":"Mansoor","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Hospitals Cleveland Medical Center  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohannad","family":"Abou Saleh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.286"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-006-0023-7"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2006.11.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13614"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.01.008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00498"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.09.037"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2012.01236.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03945.x"},{"key":"e_1_2_5_13_1","unstructured":"IBM Corporation.The IBM Explorys Platform: liberate your healthcare data.https:\/\/www.ibm.com\/downloads\/cas\/4P0QB9JN. 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