{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:27:28Z","timestamp":1778718448717,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013415","name":"Purdue University Center for Cancer Research","doi-asserted-by":"publisher","award":["KMU\u2010TC108A04\u20103"],"award-info":[{"award-number":["KMU\u2010TC108A04\u20103"]}],"id":[{"id":"10.13039\/100013415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Chronic hepatitis C virus (HCV) infection is associated with impaired renal function. The aim of this study is to explore the risk of and factors associated with end\u2010stage renal diseases (ESRD) under maintenance dialysis among HCV patients after anti\u2010HCV therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 12\u00a0696 HCV\u2010infected patients with interferon\u2010based therapy, including 9679 (76.2%) achieving sustained virological response (SVR), were enrolled from 23 hospitals in Taiwan.<\/jats:p><\/jats:sec>Results<\/jats:title>During a mean follow\u2010up period of 5.3\u00a0years (67\u00a0554 person\u2010years), the annual incidence of 4.1\/10\u00a0000 person\u2010years, 4.0\/10\u00a0000 and 4.7\/10\u00a0000 person\u2010years among SVR patients and non\u2010SVR patients, respectively. History of diabetes and baseline estimated glomerular filtration rate\u00a0<\u00a060\u00a0mL\/min\/m2<\/jats:sup>, instead of SVR, were the significant risk factors for developing ESRD with maintenance dialysis after anti\u2010HCV therapy (adjusted hazard ratio 7.75 and 9.78).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Diabetes and baseline impaired renal function were strongly associated with progression to ESRD with maintenance dialysis among chronic HCV\u2010infected patients after antiviral therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15469","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T11:50:00Z","timestamp":1614167400000},"page":"2247-2254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term risk of end\u2010stage renal diseases with maintenance dialysis among chronic hepatitis C patients after antiviral therapy in Taiwan"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9739-3901","authenticated-orcid":false,"given":"Meng\u2010Hsuan","family":"Hsieh","sequence":"first","affiliation":[{"name":"Health Management Center, Department of Occupational and Environmental Medicine Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center Kaohsiung Medical University Hospital Kaohsiung Taiwan"},{"name":"School of Medicine and Hepatitis Research Center, College of Medicine, and Center for Cancer Research and Center for Liquid Biopsy and Cohort Research Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"Institute of Biomedical Sciences National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Jong","family":"Bair","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal 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