{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:07:48Z","timestamp":1758636468603,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The evidence of associations between some types of advanced colorectal neoplasia (ACN) at baseline and the risk of metachronous neoplasia is inconsistent. This study aimed to elucidate the incidence of metachronous neoplasia during post\u2010polypectomy surveillance in individuals with ACN at baseline and examine the risk factors for its high incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from individuals who underwent endoscopic resection for ACN and received surveillance colonoscopy were analyzed. Data from individuals with no neoplastic lesions at baseline were used as reference. The incidence of metachronous ACN and clinically significant neoplasia (ACN and nonadvanced adenomas sized \u2265\u00a05\u00a0mm) were evaluated. Risk factors for the higher incidence of these lesions were examined in individuals with ACN at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the median follow\u2010up period of 61.8\u00a0months, metachronous ACN and nonadvanced adenomas sized \u2265\u00a05\u00a0mm were detected in 9.6% and 32.4% of individuals with ACN at baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a0136), respectively. The cumulative incidence of metachronous ACN and clinically significant neoplasia in individuals with ACN at baseline (3\u2010year incidence: 5.5% and 16.9%, respectively) was higher than that in individuals with no neoplastic lesions at baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 for both). The presence of advanced histology at baseline, \u2265\u00a05 neoplastic lesions at baseline, and family history of colorectal cancer were identified as risk factors for the higher incidence of clinically significant neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The relatively high incidence of metachronous neoplasia in individuals with ACN at baseline was confirmed; careful surveillance is required for these individuals, particularly in those with the risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15471","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T00:14:31Z","timestamp":1614212071000},"page":"2230-2238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of metachronous neoplastic lesions during post\u2010polypectomy surveillance in individuals with advanced colorectal neoplasia at initial screening colonoscopy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-6896","authenticated-orcid":false,"given":"Masau","family":"Sekiguchi","sequence":"first","affiliation":[{"name":"Cancer Screening Center National Cancer Center Hospital  Tokyo Japan"},{"name":"Division of Screening Technology Center for Public Health Sciences, National Cancer Center  Tokyo Japan"},{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Kakugawa","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takamaru","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Saito","sequence":"additional","affiliation":[{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Cancer Screening Center National Cancer Center Hospital  Tokyo Japan"},{"name":"Division of Screening Technology Center for Public Health Sciences, National Cancer Center  Tokyo Japan"},{"name":"Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-309086"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100370"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.10.026"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1185-3109"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319858"},{"key":"e_1_2_6_8_1","first-page":"1519","article-title":"Japan Gastroenterological Endoscopy Society. Colonoscopy screening and surveillance guidelines","volume":"8","author":"Saito Y","year":"2020","journal-title":"Gastroente Endo"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-4-201208210-00002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2014.11"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12904"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.221168"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1433-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0209-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000261"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.01.033"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14851"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15116"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007203430301"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5157(03)00053-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1021-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/11024150152707770"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314005"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321996"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyp047"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13516"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.15471","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:30:45Z","timestamp":1693204245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.15471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/jgh.15471"],"URL":"https:\/\/doi.org\/10.1111\/jgh.15471","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"type":"print","value":"0815-9319"},{"type":"electronic","value":"1440-1746"}],"subject":[],"published":{"date-parts":[[2021,3,25]]},"assertion":[{"value":"2021-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}