{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:30:27Z","timestamp":1747186227376,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Quinolones are globally popular antibiotics with proven potency, broad coverage, and reasonable safety. However, some concerns were raised as to their possible association with acute liver failure (ALF). The aim of this study is to assess ALF risk within 30\u00a0days of receiving a systemically administered quinolone antibiotic, in individuals with no history of liver\/diseases<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nested case\u2013control study using electronic health records from the Cerner Health Facts. The initial cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a035\u00a0349\u00a0943) included all patients who were admitted between 2000 and 2016, with no history of liver diseases, and had a minimum medical history of one year. Eligible cases were inpatients who were first diagnosed with ALF between 2010 and 2015. Using incidence density sampling, each case was matched with up to five unique controls by sex, race, age at index encounter, and period\u2010at\u2010risk. We used conditional logistic regression to calculate the odds ratio and 95% confidence interval for ALF risk, upon adjusting for exposure to other medications, and major confounders (diabetes mellitus and alcohol abuse). We used the STROBE Statement for reporting on our study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 3151 cases and 15\u00a0657 controls. Our primary analysis did not reveal an association between quinolones and ALF risk. However, some risk was identified among those with no or few comorbidities, those \u2264\u00a060\u00a0years of age, women, men, African Americans, and Caucasians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although our study does not suggest an overall association between quinolones and ALF, elevated risks seen in some subgroups warrant further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15504","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T12:13:58Z","timestamp":1616501638000},"page":"2307-2314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systemic quinolones and risk of acute liver failure III: A nested case\u2013control study using a US electronic health records database"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-7512","authenticated-orcid":false,"given":"Mohamed Kadry","family":"Taher","sequence":"first","affiliation":[{"name":"McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"},{"name":"Risk Sciences International  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A G","family":"Crispo","sequence":"additional","affiliation":[{"name":"McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"Department of Neurology University of Pennsylvania Perelman School of Medicine  Philadelphia Pennsylvania USA"},{"name":"Human Sciences Division Northern Ontario School of Medicine  Sudbury Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Fortin","sequence":"additional","affiliation":[{"name":"McLaughlin Centre for Population Health Risk Assessment, Faculty of Medicine University of Ottawa  Ottawa Ontario Canada"},{"name":"Statistics Canada  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Moog","sequence":"additional","affiliation":[{"name":"Cerner Corporation  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0965-883X","authenticated-orcid":false,"given":"Douglas","family":"McNair","sequence":"additional","affiliation":[{"name":"Bill &amp; 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