{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:58:50Z","timestamp":1781294330048,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastrointestinal (GI) lesions may have subtle morphological changes. Linked color imaging (LCI) combines narrow\u2010band wavelength light and white light imaging (WLI) in appropriate balance to enhance lesion detection. We compared the detection rates of upper GI lesions using LCI and WLI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients were randomized in a 1:1 ratio to receive tandem gastroscopy with WLI inspection followed by LCI, or vice versa. Endoscopic examination was performed using the EG\u2010L590ZW gastroscope and the LASEREO endoscope system (Fujifilm Co., Tokyo, Japan). Histology was reported by a specialist GI pathologist blinded to the technique of lesion detection and was used as the gold standard for diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety patients (mean age 66.8\u00a0years, 51.5% male patients) were randomized to either LCI examination first followed by WLI (LCI\u2010WLI), or vice versa (WLI\u2010LCI). An 18.9% of gastroscopies in the study were for surveillance of previously known gastric cancer precursors. Ten patients (11.1%) had a history of <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> infection. There was no significant difference in the time taken for examination under LCI (311\u00a0\u00b1\u00a096\u00a0s) and WLI (342\u00a0\u00b1\u00a086\u00a0s) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.700). LCI detection rates were higher than WLI detection rates for gastric cancer precursors such as atrophic gastritis (2.19% <jats:italic>vs<\/jats:italic> 0.55%) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and intestinal metaplasia (19.73% <jats:italic>vs<\/jats:italic> 7.67%) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Both sensitivity (82.74% <jats:italic>vs<\/jats:italic> 50.96%) and specificity (98.71% <jats:italic>vs<\/jats:italic> 96.10%) of LCI were higher than WLI for detection of upper GI lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Linked color imaging had better detection rates, sensitivity, and specificity for detection of upper GI lesions compared with WLI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15515","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T04:49:55Z","timestamp":1617425395000},"page":"2562-2567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A prospective randomized tandem gastroscopy pilot study of linked color imaging <i>versus<\/i> white light imaging for detection of upper gastrointestinal lesions"],"prefix":"10.1111","volume":"36","author":[{"given":"Clement Chun Ho","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikneswaran","family":"Namasivayam","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-4278","authenticated-orcid":false,"given":"James Weiquan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris JL","family":"Khor","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwong Ming","family":"Fock","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngai Moh","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai Mun","family":"Wang","sequence":"additional","affiliation":[{"name":"Duke\u2010NUS Medical School  Singapore"},{"name":"Department of Laboratory Medicine, Section of Pathology Changi General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9993-8549","authenticated-orcid":false,"given":"Tiing Leong","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Changi General Hospital  Singapore"},{"name":"Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.012211"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2015.05.012"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2015.20.1.25"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000226765"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.12.012"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2431-x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.30458"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000478"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12205"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0580-7405"},{"key":"e_1_2_5_12_1","article-title":"Linked color imaging can improve detection rate of early gastric cancer in a high\u2010risk population: a multi\u2010center randomized controlled clinical trial","author":"Gao J","year":"2020","journal-title":"Dig. 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