{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:14:38Z","timestamp":1768454078490,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900546"],"award-info":[{"award-number":["81900546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2016209"],"award-info":[{"award-number":["A2016209"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The evidences for use of postoperative antibiotics (POA) in hepatocellular carcinoma (HCC) patients who underwent hepatectomy are controversial. We aimed to explore the relationship between POA and hepatectomy\u2010related infection in a hepatitis B virus (HBV)\u2010related HCC population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected 934 HCC patients who underwent hepatectomy for curative intent from three tertiary hospitals in China. The incidences of postoperative infection including surgical site infection and remote site infection were recorded and calculated. Univariable and multivariable logistic regression analyses were performed to explore related factors of postoperative infection and POA. And the relationship between infection rates with different durations of POA was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall infection rate was 8.2% (77\/934), including 6.5% (61\/934) of surgical site infection and 2.0% (19\/934) of remote site infection. Multivariable analysis revealed that the administration of POA was negatively related with the incidence of postoperative infection significantly (odds ratio\u00a0=\u00a00.50, 95% confidence interval\u00a0=\u00a00.30 to 0.83; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Albumin\u2010bilirubin score, Barcelona Clinic Liver Cancer (BCLC) stage and extent of hepatectomy were independently related to the POA. And 3\u2010day regimen seemed to be the shortest duration of POA to gain the lowest incidence of postoperative infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postoperative antibiotic is necessary for HBV\u2010related HCC patients to prevent postoperative infection, especially for those with higher albumin\u2010bilirubin score, at BCLC stage B\u2013C, or who underwent major hepatectomy. For HBV\u2010related HCC patients, postoperative second\u2010generation cephalosporins, or ceftriaxone for 3\u00a0days after surgery might be proper.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15528","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T01:10:22Z","timestamp":1620177022000},"page":"2531-2539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Three\u2010day postoperative antibiotics reduces post\u2010hepatectomy infection rate in hepatitis B virus\u2010related hepatocellular carcinoma"],"prefix":"10.1111","volume":"36","author":[{"given":"Zebin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Liver Surgery The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery 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