{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:29:58Z","timestamp":1789388998179,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Approximately half of patients with Crohn's disease (CD) who have surgery will experience clinical recurrence within 10\u00a0years of their surgery. This study aimed to assess the postoperative outcomes according to disease location and validated the simple endoscopic score for CD (SES\u2010CD) to predict disease\u2010related outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed medical records of CD patients who underwent ileocolonoscopy within 12\u00a0months after surgery at the University of Chicago between 2005 and 2016. We defined patients with postoperative colonic inflammation at the first postoperative ileocolonoscopy or had Montreal classification L2 as colon\u2010dominant disease and patients without colonic involvement or who had L1 as small intestine (SI)\u2010dominant disease. The outcomes included clinical and surgical recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 207 CD patients, 51 (24.6%) and 156 (75.4%) patients had colon\u2010dominant and SI\u2010dominant disease, respectively. Patients with colon\u2010dominant disease had a greater risk of postoperative clinical recurrence compared with those with SI\u2010dominant disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018). Colon\u2010dominant disease was a risk of earlier surgical recurrence compared with SI\u2010dominant disease, although there were no significant differences in the recurrence\u2010free survivals. SES\u2010CD\u00a0&gt;\u00a02 at the first postoperative ileocolonoscopy was a significant risk of clinical recurrence on log\u2010rank test (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and Cox proportional hazards model (hazard ratio\u00a0=\u00a02.25; 95% confidence interval\u00a0=\u00a01.14\u20134.47; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.020). An SES\u2010CD of 1 was an appropriate cut\u2010off to predict the clinical recurrence of SI\u2010dominant disease, but a higher SES\u2010CD cut\u2010off value of 5 was required for colon\u2010dominant disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated that SES\u2010CD predicts postoperative clinical recurrence of CD, regardless of disease location.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15540","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T08:21:16Z","timestamp":1620721276000},"page":"2785-2793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Predictability of simple endoscopic score for Crohn's disease for postoperative outcomes in Crohn's disease"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-7638","authenticated-orcid":false,"given":"Shintaro","family":"Akiyama","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"},{"name":"Section of Gastroenterology, Department of Internal Medicine Toho University Sakura Medical Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7954-0699","authenticated-orcid":false,"given":"Jacob E","family":"Ollech","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"},{"name":"Inflammatory Bowel Disease Center, Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuga","family":"Komaki","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"},{"name":"Digestive and Lifestyle Diseases Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukiko","family":"Komaki","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"},{"name":"Digestive and Lifestyle Diseases Kagoshima University Graduate School of Medical and Dental Sciences  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Pekow","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushila R","family":"Dalal","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell D","family":"Cohen","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-1723","authenticated-orcid":false,"given":"David T","family":"Rubin","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-6129","authenticated-orcid":false,"given":"Atsushi","family":"Sakuraba","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois 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