{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:07:24Z","timestamp":1792098444025,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T00:00:00Z","timestamp":1624924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","award":["3D5157573428"],"award-info":[{"award-number":["3D5157573428"]}],"id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The biological characterization of microbial environment in early gastric cancer (EGC), other than <jats:italic>Helicobacter pylori<\/jats:italic>, is limited. This study aimed to explore the microbial microenvironment in chronic gastritis (CG), fundic gland polyps (FGPs), low\u2010grade intraepithelial neoplasia (LGIN), and EGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>16S\u2010rRNA gene sequencing and bioinformatic analysis were performed on 63 individuals with 252 mucosal biopsies or endoscopic submucosal dissection margin samples from endoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The microbiota in gastric LGIN functions analogously to EGC in terms of functional prediction. Neoplastic lesions showed a significant difference to CG or FGPs in beta diversity of the microbiota. Bacteria genera including <jats:italic>Paracoccus<\/jats:italic>, <jats:italic>Blautia<\/jats:italic>, <jats:italic>Barnesiella<\/jats:italic>, <jats:italic>Lactobacillus<\/jats:italic>, <jats:italic>Thauera<\/jats:italic>, <jats:italic>Collinsella<\/jats:italic> were significantly enriched in gastric neoplastic mucosa (LGIN and EGC) compared with non\u2010neoplastic tissues (CG and FGPs). While <jats:italic>Pseudomonas<\/jats:italic> and <jats:italic>Kingella<\/jats:italic> were depleted in neoplastic tissues. FGPs showed a distinctive microbial network system that negatively interacted with <jats:italic>Helicobacter<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In terms of the mucosal microbial microenvironment, gastric LGIN and EGC showed no significant difference as early neoplastic lesions. We observed a coordinated microbial microenvironment that correlated negatively with <jats:italic>Helicobacter<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15565","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T17:13:43Z","timestamp":1622913223000},"page":"3092-3101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mucosal microbial microenvironment in early gastric neoplasia and non\u2010neoplastic gastric disease"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-7826","authenticated-orcid":false,"given":"Fudong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Endoscopy Center The First Hospital of Jilin University  Changchun 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