{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T21:14:06Z","timestamp":1787606046943,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      eradication can disrupt the gut microbiome. Here, we investigated the short\u2010term impact of minimum antibiotic treatment\u2014a 7\u2010day vonoprazan and low\u2010dose amoxicillin regimen (VA\u2010dual therapy)\u2014on gut microbiota and compared it with that of vonoprazan\u2010based triple therapy (VAC\u2010triple therapy).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010nine patients with\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      infection were recruited (UMIN000034140) from March to May 2019 and randomly assigned to the VAC\u2010triple therapy or VA\u2010dual therapy groups, according to the first\u2010line\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>H.\u00a0pylori<\/jats:italic>\n                      <\/jats:styled-content>\n                      treatment received. Fecal samples were collected before treatment initiation and 1 and 8\u00a0weeks after eradication therapy completion. The composition ratios of the bacterial taxa and the alpha and beta diversities were evaluated in both groups via polymerase chain reaction amplification of the V3\u2013V4 region of the 16S rRNA gene and sequencing using the MiSeq system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen patients were assigned to the VA\u2010dual group and 24 to the VAC\u2010triple group. Compared with baseline, the alpha diversity reduced significantly 1 and 8\u00a0weeks after VAC\u2010triple therapy. However, for VA\u2010dual therapy, the alpha diversities at 1 and 8\u00a0weeks after the treatment did not change significantly compared with those at baseline. Additionally, the beta diversity differed significantly between baseline and 1 and 8\u00a0weeks after VAC\u2010triple therapy. VAC\u2010triple therapy led to significant alteration in the relative abundance of Actinobacteria at the phylum level and\n                      <jats:italic>Collinsella<\/jats:italic>\n                      ,\n                      <jats:italic>Blautia<\/jats:italic>\n                      , and\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      at the genus level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared with VAC\u2010triple therapy, VA\u2010dual therapy induced minimal changes in the diversity and relative abundance of gut microbiota.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15572","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T18:16:08Z","timestamp":1623262568000},"page":"3314-3321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Lower impact of vonoprazan\u2013amoxicillin dual therapy on gut microbiota for\n                    <i>Helicobacter pylori<\/i>\n                    eradication"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-2434","authenticated-orcid":false,"given":"Toshiki","family":"Horii","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"},{"name":"Department of Gastroenterology Yuri Kumiai General Hospital Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-1409","authenticated-orcid":false,"given":"Sho","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Takano","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Ichijima","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chika","family":"Kusano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatomo","family":"Ikehara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Gotoda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00510.x"},{"key":"e_1_2_6_3_1","first-page":"137","article-title":"Clinical onset of the Crohn's disease after eradication therapy of Helicobacter pylori infection. 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