{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:31:58Z","timestamp":1783506718184,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030_166670"],"award-info":[{"award-number":["320030_166670"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Previous studies have shown a reduction of gastrointestinal symptoms in irritable bowel syndrome (IBS) patients following a low FODMAP diet (LFD). It remains unknown which disorders of gut\u2013brain interaction (DGBI) patients would benefit most from LFD. We aimed to analyze LFD response regarding a preceding nutrient challenge test (NCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of 110 consecutive DGBI patients undergoing NCT and LFD between August 2015 and August 2018 were analyzed retrospectively. LFD response was assessed by changes in IBS Symptom Severity Score (IBS\u2010SSS). In mixed\u2010effects linear regression models, the impact of hydrogen values and abdominal symptoms during NCT, performed with 30\u2010g lactulose and 400\u2010mL liquid test meal, on IBS\u2010SSS changes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low FODMAP diet induced a significant IBS\u2010SSS reduction of 78 points (95% confidence interval [CI] 50\u201396;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Patients with higher NCT\u2010induced hydrogen increase during proximal intestinal transit had a significantly better LFD response (\u221266 IBS\u2010SSS reduction per 10\u2010ppm hydrogen increase, 95% CI \u2212129 to \u22124,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.045). Additionally, the higher the NCT\u2010induced maximum hydrogen increase during mid\u2010distal and distal intestinal transit, the better are the responses to LFD (\u22126 IBS\u2010SSS per 10\u2010ppm maximum delta hydrogen, 95% CI \u221211 to \u22121,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.040). There was no association of LFD response with abdominal symptom generation during NCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study is the first one analyzing and demonstrating significant associations between NCT results and LFD response. These findings are of high clinical importance, as they identify a subgroup of DGBI patients that may profit most from a restrictive LFD as first\u2010line therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15573","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T21:56:06Z","timestamp":1623275766000},"page":"3322-3328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Better response to low FODMAP diet in disorders of gut\u2013brain interaction patients with pronounced hydrogen response to a nutrient challenge test"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5112-8504","authenticated-orcid":false,"given":"Valeria","family":"Schindler","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital of Z\u00fcrich Z\u00fcrich 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