{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:41:56Z","timestamp":1785829316637,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The thymosin beta 10 (TMSB10) was originally identified from the thymus, which plays a key role in the development of many cancers. However, the underlying molecular mechanisms of TMSB10 involved in GC have not been understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We sought to determine the expression of TMSB10 in human GC tissues and illustrate whether it is correlated with the clinical pathologic characteristics and prognosis in GC patients. Its roles and potential mechanisms in regulating tumor growth, invasion, and angiogenesis were evaluated by TMSB10 knockdown\/overexpression of GC cells <jats:italic>in vitro<\/jats:italic> and <jats:italic>ex vivo<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Marked overexpression of TMSB10 protein expression was observed in GC cells and tissues, which was associated with the advanced tumor stage and lymph nodes (LN) metastasis of GC patients. Furthermore, prognostic analysis showed that GC patients with high TMSB10 expression had a remarkably shorter survival and acted as an important factor for predicting poor overall survival in GC patients. Moreover, TMSB10 overexpression promoted, while TMSB10 knockdown the proliferation, EMT process, and angiogenesis of GC cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study highlights that TMSB10 may hold promise as potential prognosis prediction biomarker for the diagnosis of GC and a potential therapeutic target, which will facilitate the development of a novel therapeutic strategy against GC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15576","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T11:54:41Z","timestamp":1623412481000},"page":"3102-3112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["TMSB10, a potential prognosis prediction biomarker, promotes the invasion and angiogenesis of gastric cancer"],"prefix":"10.1111","volume":"36","author":[{"given":"ZhenKun","family":"Yan","sequence":"first","affiliation":[{"name":"Endoscopy Center China\u2010Japan Union Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaomei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurology Qianwei Hospital of Jilin Province  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology Tumor Hospital of Jilin Province  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3152-307X","authenticated-orcid":false,"given":"Liqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Endoscopy Center China\u2010Japan Union Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2018.01.01"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-017-0575-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4528"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.7.2536"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146708"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130040"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061960"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.03.058"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.545798"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7817-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi316"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210078"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206404"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00462-3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.041335"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-011-9467-7"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.06.023"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072502760339325"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204683"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-430"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.03.054"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.01.017"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2018_181123N890"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.113775"},{"key":"e_1_2_7_27_1","first-page":"3759","article-title":"Overexpression of thymosin beta10 correlates with disease progression and poor prognosis in bladder cancer","volume":"18","author":"Wang B","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910480507"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.05.066"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0785-2"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-430"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-011-0073-z"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3359"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20182355"},{"key":"e_1_2_7_35_1","first-page":"305","article-title":"TMSB10 promotes migration and invasion of cancer cells and is a novel prognostic marker for renal cell carcinoma","volume":"12","author":"Xiao R","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000138"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl239"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017799"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-81"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2012.756111"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.137.65.1"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000163220"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.15576","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:04:48Z","timestamp":1693220688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.15576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,26]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jgh.15576"],"URL":"https:\/\/doi.org\/10.1111\/jgh.15576","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,26]]},"assertion":[{"value":"2021-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}