{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:12:30Z","timestamp":1790694750552,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Sodium\u2010glucose cotransporter 2 inhibitors have shown excellent results in glucose control in type 2 diabetes mellitus (T2DM) patients, while also promoting weight loss. These mechanisms may be beneficial in the treatment of non\u2010alcoholic fatty liver disease (NAFLD). Our study aims to investigate the effect of dapagliflozin on hepatic and visceral fat contents and related biochemical markers in T2DM with NAFLD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a double\u2010blinded placebo\u2010controlled randomized, single\u2010center study. Non\u2010insulin\u2010dependent T2DM patients with NAFLD were prospectively enrolled and randomly assigned to receive either dapagliflozin (10\u00a0mg\/day) or placebo for 12\u00a0weeks. The primary end\u2010point was the changes in intrahepatic lipid contents, evaluated by the liver attenuation index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 40 patients enrolled, 38 patients completed the study (dapagliflozin group, <jats:italic>n<\/jats:italic>\u00a0=\u00a018; placebo group, <jats:italic>n<\/jats:italic>\u00a0=\u00a020). Baseline demographic and laboratory findings were similar in both groups. After 12\u00a0weeks of treatment, dapagliflozin significantly decreased intrahepatic lipid contents demonstrated by an increase in liver attenuation index in comparison with the placebo treatment (5.8\u00a0\u00b1\u00a05.1 <jats:italic>vs<\/jats:italic> 0.5\u00a0\u00b1\u00a06.1 Hounsfield units, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). Significant reduction in bodyweight, bodyfat, visceral fat\/subcutaneous fat ratio, hemoglobin A1c, and alanine aminotransferase were also observed in the dapagliflozin\u2010treated group as compared with the placebo group (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). There was no significant difference in adipokines including adiponectin, leptin, and tumor necrosis factor\u2010\u03b1 changes between the dapagliflozin\u2010treated group and the placebo group (all <jats:italic>P<\/jats:italic>\u00a0=\u00a0nonsignificant).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dapagliflozin treatment for 12\u00a0weeks is associated with improvement in hepatic fat content, a decrease in visceral fat and bodyweight, enhanced glycemic control, and improved liver biochemistry among T2DM patients with NAFLD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15580","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:27:16Z","timestamp":1623763636000},"page":"2952-2959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["The effects of dapagliflozin on hepatic and visceral fat in type 2 diabetes patients with non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"36","author":[{"given":"Susrichit","family":"Phrueksotsai","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-7582","authenticated-orcid":false,"given":"Kanokwan","family":"Pinyopornpanish","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntima","family":"Euathrongchit","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apinya","family":"Leerapun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arintaya","family":"Phrommintikul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supawan","family":"Buranapin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-718X","authenticated-orcid":false,"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Research and Training Center, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine Chiang Mai University  Chiang Mai 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