{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:21:57Z","timestamp":1781810517263,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>This study aimed to investigate the relationship between hepatic steatosis (HS) evaluated by biopsy and visceral adiposity assessed by computed tomography in lean living liver donor candidates and to determine the risk factors for lean non\u2010alcoholic fatty liver disease (NAFLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 250 lean (body mass index, &lt;\u00a023\u00a0kg\/m<jats:sup>2<\/jats:sup>) potential living liver donors (mean age, 31.1\u00a0\u00b1\u00a08.6\u00a0years; 141 men) who had undergone liver biopsy and abdominal computed tomography between 2017 and 2018. Anthropometry, laboratory parameters, body composition, and the degree of HS were evaluated. Logistic regression was used to identify independent predictors of lean NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The visceral fat area (VFA) was significantly correlated with the degree of HS in men (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.408; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and women (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.360; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The subcutaneous fat area was significantly correlated with the degree of HS in men (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.398; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but not in women. The skeletal muscle area did not correlate with the degree of HS in either men or women. In the multivariable logistic regression analysis, the VFA (odds ratio [OR], 1.028; 95% confidence interval [CI], 1.013\u20131.044; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and subcutaneous fat area (OR, 1.016; 95% CI, 1.004\u20131.028; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.009) were independent risk factors for lean NAFLD in men, and the VFA (OR, 1.036; 95% CI, 1.013\u20131.059; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) was an independent risk factor for lean NAFLD in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The severity of non\u2010alcoholic fatty liver was positively correlated with visceral fat accumulation in a lean Asian population. Visceral adiposity may be a risk factor for lean NAFLD in potential living liver donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15597","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T02:34:56Z","timestamp":1624588496000},"page":"3212-3218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Visceral adiposity as a risk factor for lean non\u2010alcoholic fatty liver disease in potential living liver donors"],"prefix":"10.1111","volume":"36","author":[{"given":"Sunyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiology and Research Institute of Radiological Science, Severance Hospital Yonsei University College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6471-6727","authenticated-orcid":false,"given":"Kyoung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongjin","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering Soongsil University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeyong","family":"Park","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering Soongsil University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungwoo","family":"Khang","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering Soongsil University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeryeol","family":"Jeong","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering Soongsil University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi\u2010Won","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_5_4_1","first-page":"216","article-title":"Non\u2010alcoholic fatty liver disease in lean subjects: characteristics and implications","volume":"5","author":"Kumar R","year":"2017","journal-title":"J. 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