{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:06:09Z","timestamp":1765713969628,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ABC test measures serum pepsinogen and anti\u2010<jats:italic>Helicobacter pylori<\/jats:italic> IgG antibody levels to predict precancerous conditions in the stomach and gastric cancer. However, a limitation of this test is that the gastric cancer risk is not negligible in patients with a negative result.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on their ABC results, 1157 patients were classified into Groups A (<jats:italic>n<\/jats:italic>\u00a0=\u00a0392), B (<jats:italic>n<\/jats:italic>\u00a0=\u00a0479), C (<jats:italic>n<\/jats:italic>\u00a0=\u00a0247), and D (<jats:italic>n<\/jats:italic>\u00a0=\u00a039). In Group A, 24.2% of patients had atrophic gastritis and\/or intestinal metaplasia and had thus been incorrectly assigned to Group A. Patients in Group A were then assigned to derivation (<jats:italic>n<\/jats:italic>\u00a0=\u00a0236) and validation (<jats:italic>n<\/jats:italic>\u00a0=\u00a0156) cohorts by 3:2 random sampling. Logistic regression analyses were performed to identify the factors discriminating between a correct (true) and incorrect (false) Group A classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 4\u2010point discriminative model was constructed based on a high\u2010negative <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content> IgG antibody titer and the patient's age (50\u201364 and \u226565\u00a0years). The areas under the receiver operating characteristic curve for the derivation and validation cohorts were 0.868 and 0.894, respectively. In the validation cohort, the addition of a discriminative model score \u22652 to the ABC method showed a similar accuracy for predicting gastric cancer risk compared with the ABC method alone (93.8% vs. 92.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The 4\u2010point discriminative model may help identify patients with a normal serological test who are nonetheless at risk of developing gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15630","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T11:17:21Z","timestamp":1626693441000},"page":"3345-3353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Scoring model for discriminating gastric cancer risk in patients with negative serum pepsinogen and anti\u2010<i>Helicobacter pylori<\/i> antibody results"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-2333","authenticated-orcid":false,"given":"Jun\u2010Hyung","family":"Cho","sequence":"first","affiliation":[{"name":"Digestive Disease Center Soonchunhyang University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u2010Young","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology Soonchunhyang University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Biostatistics Soonchunhyang University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2011.00859.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00550.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90176-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02774209"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11680"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.3521-19"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4450-20"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007603"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02347560"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.87.405"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13676"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v8.i14.2902"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.728"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14383"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(95)00068-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1315739"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.055400"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.09.013"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i43.4793"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12101"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12669"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000469705"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-018-1431-9"},{"key":"e_1_2_6_27_1","first-page":"85","article-title":"Long\u2010term follow\u2010up of Helicobacter pylori serology after successful eradication","volume":"91","author":"Cutler AF","year":"1996","journal-title":"Am. 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