{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:52:36Z","timestamp":1792633956046,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973936"],"award-info":[{"award-number":["81973936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The therapeutic effect of acupuncture treatments (AT) on functional gastrointestinal disorders (FGIDs) is contentious. A meta\u2010analysis was conducted to assess the efficacy and safety of acupuncture for FGIDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Cochrane Library, EMBASE, PUBMED, Web of Science, Wanfang Database, China National Knowledge Infrastructure, and VIP Database were searched through December 31, 2019 with no language restrictions. Risk ratio (RR) with 95% confidence interval (CI) was calculated to determine the improvement in symptom severity after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 61 randomized controlled trials (RCTs) on FGIDs were included. The pooled results illustrated the following: compared to pharmacotherapy (RR 1.13, 95% CI 1.09\u20131.17), placebo acupuncture (RR 1.69, 95% CI 1.37\u20132.08), no specific treatment (RR 1.86, 95% CI 1.31\u20132.62), and AT as an adjuvant intervention to other active treatments (RR 1.25, 95% CI 1.21\u20131.30), AT had more favorable improvements in symptom severity; sub\u2010group analysis results classified according to functional dyspepsia, irritable bowel syndrome, and functional constipation also supported this finding; and the incidence of adverse events was lower in AT than in other treatments (RR 0.75, 95% CI 0.56\u20130.99).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis found that AT was significantly associated with relief of FGIDs symptoms; however, the evidence level was moderate or low. Further data from rigorously designed and well powered RCTs are needed to verify the effectiveness and safety of AT as a FGIDs treatment.<\/jats:p><jats:p><jats:bold>PROSPERO PROTOCOL NUMBER<\/jats:bold>: CRD42020169508.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15645","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T07:27:07Z","timestamp":1627975627000},"page":"3015-3026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Acupuncture for functional gastrointestinal disorders: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-3733","authenticated-orcid":false,"given":"Xi\u2010yang","family":"Wang","sequence":"first","affiliation":[{"name":"School of Integrated Chinese and Western Medicine Anhui University of Chinese Medicine Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine Anhui University of Chinese Medicine Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010yuan","family":"Guan","sequence":"additional","affiliation":[{"name":"Department Acupuncture and Rehabilitation The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010lin","family":"Cai","sequence":"additional","affiliation":[{"name":"Research Institute of Acupuncture and Moxibustion Anhui University of Chinese Medicine Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010ming","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Integrated Chinese and Western Medicine Anhui University of Chinese Medicine Hefei Anhui Province China"},{"name":"Institute of Integrated Chinese and Western Medicine Anhui University of Chinese Medicine Hefei Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.03.035"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-200901001-00002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02196.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.03.008"},{"key":"e_1_2_7_8_1","volume-title":"The Functional Gastrointestinal Disorders: Diagnosis, Pathophysiology, and Treatment: A Multinational Consenus","author":"Drossman DA","year":"1994"},{"key":"e_1_2_7_9_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins J","year":"2011"},{"key":"e_1_2_7_10_1","first-page":"585","article-title":"Clinical value of compound digestive enzyme capsule combined with acupuncture in the treatment of functional dyspepsia","volume":"28","author":"Wang W","year":"2019","journal-title":"Chin. J. Convalescent. Med."},{"key":"e_1_2_7_11_1","first-page":"1165","article-title":"Observation on therapeutic effect of acupuncture at \"experienced ten acupoints\" for postprandial distress syndrome","volume":"39","author":"Kim MR","year":"2019","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14737"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13316"},{"key":"e_1_2_7_14_1","first-page":"1136","article-title":"Therapeutic observation of three\u2010segment point selection plus mosapride for functional dyspepsia","volume":"37","author":"Ye Y","year":"2018","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wjam.2018.06.004"},{"key":"e_1_2_7_16_1","first-page":"599","article-title":"Clinical study of needling the three abdominal acupoints for functional dyspepsia","volume":"37","author":"Dai M","year":"2018","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_17_1","first-page":"56","article-title":"Clinical observation on the Yuan\u2010Luo acupuncture treatment of functional dyspepsia","volume":"33","author":"Liu X","year":"2017","journal-title":"JCAM"},{"key":"e_1_2_7_18_1","first-page":"20","article-title":"Clinical curative effect and EGG changes of functional dyspepsia treated by acupuncture combined with medicine","volume":"33","author":"Jiang GD","year":"2017","journal-title":"JCAM"},{"key":"e_1_2_7_19_1","first-page":"1","article-title":"Clinical observation of acupuncture and moxibustion for functional dyspepsia with emotional disorder","volume":"32","author":"Peng KM","year":"2016","journal-title":"JCAM"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0208"},{"key":"e_1_2_7_21_1","first-page":"1636","article-title":"Ziwuliuzhu acupuncture combined with dialectical acupoints in the treatment of 60 cases with functional dyspepsia","volume":"24","author":"Zhao J","year":"2015","journal-title":"JETCM"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-015-2175-5"},{"key":"e_1_2_7_23_1","first-page":"718","article-title":"Clinical observation of acupuncture based on syndrome differentiation in improving the quality of life in patients with functional dyspepsia","author":"Zhou L","year":"2014","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_24_1","first-page":"125","article-title":"Effects of syndrome\u2010differentiation acupuncture on life quality in patients with functional dyspepsia","volume":"34","author":"Ma CY","year":"2014","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_25_1","first-page":"232","article-title":"Clinical observation of acupuncture for treatment of Pi Wei Qi deficiency functional dyspepsia","volume":"13","author":"Zheng XY","year":"2013","journal-title":"J. Trop. Med."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04979.x"},{"key":"e_1_2_7_27_1","first-page":"1071","article-title":"Long\u2010term efficacy and safety research on functional dyspepsia treated with electroacupuncture and Zhizhu Kuanzhong capsule","volume":"31","author":"Guo LK","year":"2011","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_28_1","first-page":"732","article-title":"Clinical observation of acupuncture and moxibustion in treating 90 cases of functional dyspepsia","volume":"28","author":"Shi HJ","year":"2009","journal-title":"Beijing J. Tradit. Chin. Med."},{"key":"e_1_2_7_29_1","first-page":"101","article-title":"Clinical control study on acupuncture treatment of functional dyspepsia","volume":"24","author":"Tang SX","year":"2006","journal-title":"J. Sichuan Tradit. Chin. Med."},{"key":"e_1_2_7_30_1","first-page":"267","article-title":"Clinical study on effect of acupuncture on gastrointestinal motility in the patient of functional dyspepsia","volume":"21","author":"Liu W","year":"2001","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_31_1","first-page":"1786","article-title":"Clinical study on warm acupuncture treatment of diarrhea irritable bowel syndrome with spleen\u2010stomach deficiency syndrome","volume":"40","author":"Zou W","year":"2019","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-019-1086-y"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-019-1138-3"},{"key":"e_1_2_7_34_1","first-page":"1911","article-title":"Analysis of the acupuncture combined with traditional Chinese medicine in the treatment of diarrhea\u2010predominant pattern irritable bowel syndrome patients","volume":"17","author":"Han ZC","year":"2019","journal-title":"Chin. J. Gen. Pract."},{"key":"e_1_2_7_35_1","first-page":"19","article-title":"Electroacupuncture combined with qibei mixture for diarrhea\u2010predominant irritable bowel syndrome: a randomized controlled trial","volume":"28","author":"Zhang C","year":"2018","journal-title":"WJAM"},{"key":"e_1_2_7_36_1","first-page":"1265","article-title":"Clinical effect of abdominal acupuncture for diarrhea irritable bowel syndrome","volume":"37","author":"Qin Y","year":"2017","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_37_1","article-title":"A randomized controlled study of head and body acupuncture needling method in treatment of diarrhea type irritable bowel syndrome","volume":"40","author":"Nie XN","year":"2017","journal-title":"J. Chengdu Univ. Tradit. Chin. Med."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13040"},{"key":"e_1_2_7_39_1","first-page":"9","article-title":"Acupuncture with regulating mind and spleen for diarrhea irritable bowel syndrome and sleep quality: a randomized controlled trial","volume":"37","author":"Li J","year":"2017","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_40_1","first-page":"37","article-title":"Ziwu Liuzhu acupuncture treatment of irritable bowel syndrome","volume":"31","author":"Shi ZM","year":"2015","journal-title":"JCAM"},{"key":"e_1_2_7_41_1","first-page":"1095","article-title":"Constipation predominant irritable bowel syndrome treated with acupuncture for regulating the mind and strengthening the spleen: a randomized controlled trial","volume":"35","author":"Pei L","year":"2015","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_42_1","first-page":"22","article-title":"Therapeutic observation of diarrhea\u2010predominant irritable bowel syndrome majorly treated by acupuncture with Ling Gui Ba Fa","volume":"34","author":"Li XQ","year":"2015","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_43_1","first-page":"135","article-title":"Effects and efficacy observation of acupuncture on serum 5\u2010HT in patients with diarrhea\u2010predominant irritable bowel syndrome","volume":"34","author":"Zhan DW","year":"2014","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_44_1","first-page":"1057","article-title":"Clinical observation on acupuncture for diarrhea\u2010predominant irritable bowel syndrome patients in syndrome of liver\u2010stagnation and spleen\u2010deficiency and its impact on Th1\/Th2","volume":"33","author":"Wu XL","year":"2013","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_45_1","first-page":"11","article-title":"Controlled observation on the efficacy of acupuncture and western medicine on diarrhea\u2010type irritable bowel syndrome","volume":"23","author":"Li H","year":"2013","journal-title":"WJAM"},{"key":"e_1_2_7_46_1","first-page":"43","article-title":"Efficacy observation on warm needling for 60 cases of diarrhea irritable bowel syndrome","volume":"23","author":"Ge JJ","year":"2013","journal-title":"WJAM"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-150"},{"key":"e_1_2_7_48_1","first-page":"594","article-title":"Comparison of the therapeutic effects of electroacupuncture and probiotics combined with deanxit in treating diarrhea\u2010predominant irritable bowel syndrome","volume":"32","author":"Chen YH","year":"2012","journal-title":"Chin. J. Integr. Tradit. West Med."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-011-0875-z"},{"key":"e_1_2_7_50_1","first-page":"607","article-title":"Comparative study on irritable bowel syndrome treated with acupuncture and western medicine","volume":"31","author":"Shi ZM","year":"2011","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_51_1","first-page":"510","article-title":"Clinical observation on Geshanxiaoyao decoction combining acupuncture effect on the life quality of patients with irritable bowel syndrome","volume":"34","author":"Liu QQ","year":"2010","journal-title":"J. Zhejiang Chin. Med. Univ."},{"key":"e_1_2_7_52_1","first-page":"354","article-title":"Evaluation of the therapeutic effect of acupuncture and moxibustion on irritable bowel syndrome","volume":"29","author":"An G","year":"2010","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.156"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i26.4040"},{"key":"e_1_2_7_55_1","article-title":"Li Jiao Tong Fu's needling method for functional constipation: a randomized controlled study","volume":"38","author":"Yin Y","year":"2019","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_56_1","first-page":"108","article-title":"Observation on treating functional constipation of the Xuexu Changzao type by electroacupuncture at Baliao acupoint combined with the Mibaokang decoction","volume":"10","author":"Zhang C","year":"2018","journal-title":"CJCM"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1428943"},{"key":"e_1_2_7_58_1","first-page":"130","article-title":"Clinical observation of slow transit constipation treated with acupuncture and modified weitong xiaopi formula","volume":"37","author":"Wang B","year":"2017","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_59_1","first-page":"926","article-title":"Therapeutic observation of electroacupuncture and prucalopride succinate tablets for functional constipation","volume":"35","author":"Mao Z","year":"2016","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_60_1","first-page":"761","article-title":"Acupuncture for chronic severe functional constipation: a randomized trial","volume":"165","author":"Liu Z","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"e_1_2_7_61_1","first-page":"42","article-title":"Effect of abdominal electroacupuncture on functional constipation","volume":"32","author":"Liu K","year":"2016","journal-title":"JCAM"},{"key":"e_1_2_7_62_1","first-page":"57","article-title":"A clinical randomized controlled trial of acupuncture at the combination of back\u2010shu point and front\u2010mu point of large intestine meridian in the treatment of functional constipation","author":"Zheng HB","year":"2015","journal-title":"PJCM"},{"key":"e_1_2_7_63_1","first-page":"214","article-title":"Therapeutic observation of electroacupuncture for functional constipation","author":"Xu HF","year":"2015","journal-title":"Shanghai J. Acu\u2010Mox."},{"key":"e_1_2_7_64_1","first-page":"684","article-title":"Clinical effect assessment on therapy of electric acupuncture of yangming meridian for functional constipation with slow transmission","volume":"19","author":"Zhang C","year":"2013","journal-title":"Chin. J. Basic Med. Tradit. Chin. Med."},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(13)60100-4"},{"key":"e_1_2_7_66_1","first-page":"865","article-title":"Analysis on follow\u2010up efficacy and safety of slow transit constipation treated with individualized deep puncture at Tianshu (ST 25): a multi\u2010central randomized controlled trial","volume":"33","author":"Peng WN","year":"2013","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20111108"},{"key":"e_1_2_7_68_1","first-page":"366","article-title":"Observation of deep acupuncture at tianshu for functional constipation","volume":"29","author":"Yang DL","year":"2010","journal-title":"Beijing J. Tradit. Chin. Med."},{"key":"e_1_2_7_69_1","first-page":"705","article-title":"Observation on therapeutic effect of electroacupuncture at Tianshu (ST 25) with deep needling technique on functional constipation","volume":"30","author":"Wang CW","year":"2010","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_70_1","first-page":"475","article-title":"Multi\u2010central randomized controlled trials of electroacupunture at Zhigou (TE 6) for treatment of constipation induced by stagnation or deficiency of qi","volume":"27","author":"Zhang ZL","year":"2007","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_7_71_1","first-page":"Cd005111","article-title":"Acupuncture for treatment of irritable bowel syndrome","volume":"5","author":"Manheimer E","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i23.3182"},{"key":"e_1_2_7_73_1","first-page":"CD008487","article-title":"Acupuncture for functional dyspepsia","volume":"10","author":"Lan L","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_7_74_1","doi-asserted-by":"crossref","first-page":"6137450","DOI":"10.1155\/2020\/6137450","article-title":"The Effectiveness of Acupuncture in Management of Functional Constipation: A Systematic Review and Meta\u2010Analysis","volume":"2020","author":"Wang L","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-7-31"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11409"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15645","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.15645","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.15645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T18:11:33Z","timestamp":1725559893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.15645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jgh.15645"],"URL":"https:\/\/doi.org\/10.1111\/jgh.15645","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]},"assertion":[{"value":"2020-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}