{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:41:39Z","timestamp":1788306099489,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The prevalence and incidence of eosinophilic esophagitis (EoE) has been increasing over recent years. However, the natural history remains incompletely understood particularly the differences in disease characteristics and progression of childhood\u2010onset and adult\u2010onset EoE. The aim of this study was to evaluate the disease characteristics and progression of childhood\u2010onset and adult\u2010onset EoE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional, questionnaire\u2010based study, on 87 adults and 67 children from 2 major tertiary hospitals in South Australia was conducted. Data of those who were diagnosed with EoE between 1999 and 2018 were collected and correlated with medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 87 adults with EoE, 34 (39%) were diagnosed at the age of &lt;\u00a018\u00a0years (childhood\u2010onset EoE). Reflux symptoms were more common in childhood\u2010onset EoE, whereas asthma was more common in adult\u2010onset EoE. The median duration of symptoms prior to diagnosis of EoE was &gt;\u00a01\u20134\u00a0years in childhood\u2010onset disease (44%) and \u2265\u00a010\u00a0years in adult\u2010onset disease (34%). Food impaction was significantly more common on initial presentation in those with adult\u2010onset EoE, whereas weight loss was more common in childhood\u2010onset EoE. At the time of questionnaire, regurgitation, abdominal pain, and bloating were more common in childhood\u2010onset EoE. Those with childhood\u2010onset EoE were more likely to have multiple symptoms at questionnaire when compared with their adult\u2010onset counterparts. In both groups, 15% (5\/34 childhood\u2010onset EoE and 8\/53 adult\u2010onset EoE) were asymptomatic at the time of questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Childhood\u2010onset EoE appears to be a progressive disease from childhood to adulthood, however with more inflammatory\u2010type symptoms post transition compared to those with adult\u2010onset EoE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15660","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T05:55:41Z","timestamp":1628574941000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics and progression of childhood\u2010onset and adult\u2010onset eosinophilic esophagitis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-8197","authenticated-orcid":false,"given":"Stephanie","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ellison","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Women's and Children's Hospital  North Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-7113","authenticated-orcid":false,"given":"Sara","family":"Haj Ali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Faculty of Medicine Al\u2010Balqa Applied University  Salt Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Hawkes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Women's and Children's Hospital  North Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Collinson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Women's and Children's Hospital  North Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Women's and Children's Hospital  North Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ruszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Pathology Royal Adelaide Hospital  Adelaide South 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