{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:03:43Z","timestamp":1789704223874,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Vonoprazan has more potent and sustained acid inhibitory effects than proton pump inhibitors; therefore, <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> eradication rates are expected to improve with the use of vonoprazan\u2010based regimens. To date, no randomized trial has compared the efficacy of 7\u2010day vonoprazan\u2010based triple therapy (7\u2010VAC) with 14\u2010day omeprazole\u2010based triple therapy (14\u2010OAC). This study aimed to compare the <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication rates of 7\u2010VAC and 14\u2010OAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized clinical trial was performed at a tertiary hospital in Bangkok. Patients with active <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection who were naive to treatment were included and randomized (1:1) into either a 7\u2010VAC group (vonoprazan 20\u00a0mg bid. pc., amoxicillin 1000\u00a0mg bid. pc., and clarithromycin 500\u00a0mg bid. pc.) or a 14\u2010OAC group (omeprazole 20\u00a0mg bid. ac., amoxicillin 1000\u00a0mg bid. pc., and clarithromycin 500\u00a0mg bid. pc.). Eradication success was evaluated by urea breath test 4\u20136\u00a0weeks after completion of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 122 subjects were randomized to receive 7\u2010VAC (<jats:italic>n<\/jats:italic>\u00a0=\u00a061) or 14\u2010OAC (<jats:italic>n<\/jats:italic>\u00a0=\u00a061). The <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication rates of the 7\u2010VAC and 14\u2010OAC groups were 96.7% and 88.5% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.083), respectively, by intention\u2010to\u2010treat analysis and 98.3% and 93.1% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.159), respectively, by per\u2010protocol analysis. All treatment\u2010related adverse events were mild and not significantly different between the two groups. Common side effects included bitter taste, nausea, and dizziness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 7\u2010VAC regimen was well tolerated and achieved similar eradication rates and side effects to those of 14\u2010OAC; therefore, 7\u2010VAC may be considered an alternative regimen for <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> treatment with the benefit of shorter duration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15700","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T03:01:51Z","timestamp":1633748511000},"page":"3308-3313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Randomized clinical trial: 7\u2010day vonoprazan\u2010based <i>versus<\/i> 14\u2010day omeprazole\u2010based triple therapy for <scp><i>Helicobacter pylori<\/i><\/scp>"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-032X","authenticated-orcid":false,"given":"Chalermrat","family":"Bunchorntavakul","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Rajavithi Hospital, College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunluk","family":"Buranathawornsom","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine, Rajavithi Hospital, College of Medicine Rangsit University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12514"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.04.022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2013.08.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0876-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315363"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12408"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.563"},{"key":"e_1_2_7_10_1","first-page":"2351","article-title":"Thailand consensus on Helicobacter pylori treatment 2015","volume":"17","author":"Mahachai V","year":"2016","journal-title":"Asian Pac. 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