{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:21:45Z","timestamp":1790011305394,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Functional dyspepsia (FD) is a common problem in gastroenterology practice. The study aimed to compare the efficacy of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Curcuma longa<\/jats:italic>\n                      <\/jats:styled-content>\n                      Linn\n                      <jats:italic>versus<\/jats:italic>\n                      omeprazole and placebo among patients diagnosed with FD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From November 2017 to November 2018, patients diagnosed with FD according to ROME IV criteria were enrolled. Patients were randomized into curcumin, omeprazole, or placebo groups. The Severity of Dyspepsia Assessment (SODA) was used to evaluate clinical effectiveness after 2 and 4\u00a0weeks. Health\u2010related quality of life was assessed using the EuroQol\u20105 Dimension questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 132 patients were randomized. Forty\u2010five, 43, and 44 patients were in the curcumin, omeprazole, and placebo groups, respectively. At 4\u00a0weeks, the mean SODA score change of pain and non\u2010pain symptoms decreased in the curcumin group compared with the placebo group (pain \u221216.98\u00a0\u00b1\u00a08.09\n                      <jats:italic>vs<\/jats:italic>\n                      \u221210.53\u00a0\u00b1\u00a04.43;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001, non\u2010pain \u22127.96\u00a0\u00b1\u00a03.41\n                      <jats:italic>vs<\/jats:italic>\n                      \u22126.05\u00a0\u00b1\u00a03.03;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.008). No significant difference was observed between curcumin and omeprazole groups (pain \u221216.98\u00a0\u00b1\u00a08.09\n                      <jats:italic>vs<\/jats:italic>\n                      \u221214.69\u00a0\u00b1\u00a06.41;\n                      <jats:italic>P\u00a0=<\/jats:italic>\n                      \u00a00.302, non\u2010pain \u22127.96\u00a0\u00b1\u00a03.41\n                      <jats:italic>vs<\/jats:italic>\n                      \u22127.07\u00a0\u00b1\u00a02.27;\n                      <jats:italic>P\u00a0=<\/jats:italic>\n                      \u00a00.486). The mean change of the SODA satisfaction score at 4\u00a0weeks was higher in the curcumin group compared with the omeprazole group but without statistical significance (9.17\u00a0\u00b1\u00a03.88\n                      <jats:italic>vs<\/jats:italic>\n                      8.63\u00a0\u00b1\u00a03.89,\n                      <jats:italic>P\u00a0=<\/jats:italic>\n                      \u00a01). The mean change of EQ\u20105D index at 4\u00a0weeks was highest in the curcumin group but not statistically different from other groups (0.12\u00a0\u00b1\u00a00.13\n                      <jats:italic>vs<\/jats:italic>\n                      0.09\u00a0\u00b1\u00a00.10\n                      <jats:italic>vs<\/jats:italic>\n                      0.07\u00a0\u00b1\u00a00.05;\n                      <jats:italic>P\u00a0=<\/jats:italic>\n                      \u00a00.055).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Curcuma longa<\/jats:italic>\n                      <\/jats:styled-content>\n                      Linn can improve dyspeptic symptoms, improve quality of life, and provide satisfaction equivalent to omeprazole in treatment of FD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15705","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T18:27:20Z","timestamp":1634322440000},"page":"335-341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i>Curcuma longa<\/i>\n                    Linn\n                    <i>versus<\/i>\n                    omeprazole in treatment of functional dyspepsia: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-1358","authenticated-orcid":false,"given":"Kachonsak","family":"Yongwatana","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamin","family":"Harinwan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-8504","authenticated-orcid":false,"given":"Sakkarin","family":"Chirapongsathorn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krit","family":"Opuchar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theeranun","family":"Sanpajit","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanich","family":"Piyanirun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-8034","authenticated-orcid":false,"given":"Chaipichit","family":"Puttapitakpong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1022-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.05.021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-014-9554-z"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.10.049"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.06.006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12131"},{"key":"e_1_2_6_10_1","first-page":"141","article-title":"Anti\u2010inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research","volume":"14","author":"Jurenka JS","year":"2009","journal-title":"Altern. 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