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The pooled incidence, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effects model. PROSPERO database registration no. CRD 42021230912.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 18 of the 238 studies identified met the inclusion criteria. Of the 943 patients who had SVT, 264 (28.0%) received anticoagulation. The pooled incidence of SVT at first presentation of acute pancreatitis was 15% (95% CI 5 to 26%), but was 17% (95% CI 14 to 20%) in all studies. Recanalization was more likely to occur in the anticoagulation\u2010treated than in the untreated group (OR 0.51, 95% CI 0.31 to 0.83, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). There were no differences in hemorrhagic complications (OR 2.27, 95% CI 0.81 to 6.37, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.12) or overall mortality (OR 2.37, 95% CI 0.86 to 6.52, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.10) in relation to the use of anticoagulation. The overall incidence of portal hypertension in patients was 60% (95% CI 55 to 65%). However, it was not possible to determine the incidence in each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of SVT in patients with acute pancreatitis is significant. Treatment with anticoagulants improved the odds of recanalization but did not increase the risk of hemorrhagic complications or overall mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15711","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T17:06:06Z","timestamp":1634663166000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"37","author":[{"given":"Fady S.","family":"Anis","sequence":"first","affiliation":[{"name":"Gastrointestinal Surgery Nottingham Digestive Diseases Centre and National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-6197","authenticated-orcid":false,"given":"Alfred","family":"Adiamah","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery Nottingham Digestive Diseases Centre and National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-5796","authenticated-orcid":false,"given":"Dileep N.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery Nottingham Digestive Diseases Centre and National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre  Nottingham UK"},{"name":"MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery Nottingham Digestive Diseases Centre and National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2011.00392.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200008000-00004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.09.068"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3182968ff5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2003.10.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2018.03.04"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.05.023"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.14740\/gr1223"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2011.00375.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05527.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i2.143"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S197732"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2005.03607.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i42.6168"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e318287cd3d"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_6_18_1","unstructured":"Review Manager (RevMan) [Computer program]. 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