{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:03:47Z","timestamp":1791497027338,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Because acute infectious gastroenteritis may cause post\u2010infection irritable bowel syndrome and functional dyspepsia and the severe acute respiratory syndrome coronavirus\u20102 affects gastrointestinal (GI) tract, coronavirus disease\u201019 (COVID\u201019) may cause post\u2010infection\u2010functional GI disorders (FGIDs). We prospectively studied the frequency and spectrum of post\u2010infection\u2010FGIDs among COVID\u201019 and historical healthy controls and the risk factors for its development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred eighty patients with COVID\u201019 and 264 historical healthy controls were followed up at 1 and 3\u00a0months using translated validated Rome Questionnaires for the development of chronic bowel dysfunction (CBD), dyspeptic symptoms, and their overlap and at 6\u2010month for IBS, uninvestigated dyspepsia (UD) and their overlap. Psychological comorbidity was studied using Rome III Psychosocial Alarm Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 1 and 3\u00a0months, 16 (5.7%), 16 (5.7%), 11 (3.9%), and 24 (8.6%), 6 (2.1%), 9 (3.2%) of COVID\u201019 patients developed CBD, dyspeptic symptoms, and their overlap, respectively; among healthy controls, none developed dyspeptic symptoms and one developed CBD at 3\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). At 6\u00a0months, 15 (5.3%), 6 (2.1%), and 5 (1.8%) of the 280 COVID\u201019 patients developed IBS, UD, and IBS\u2010UD overlap, respectively, and one healthy control developed IBS at 6\u00a0months (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for all except IBS\u2010UD overlap). The risk factors for post\u2010COVID\u201019 FGIDs at 6\u00a0months included symptoms (particularly GI), anosmia, ageusia, and presence of CBD, dyspeptic symptoms, or their overlap at 1 and 3\u00a0months and the psychological comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first study showing COVID\u201019 led to post\u2010COVID\u201019 FGIDs. Post\u2010COVID\u201019 FGIDs may pose a significant economic, social, and healthcare burden to the world.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15717","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T06:19:54Z","timestamp":1634797194000},"page":"489-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Post\u2010infection functional gastrointestinal disorders following coronavirus disease\u201019: A case\u2013control study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-8495","authenticated-orcid":false,"given":"Uday C","family":"Ghoshal","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow 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