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The gut\u2013liver axis plays an important role in the pathogenesis of liver disease. Small intestinal bacterial overgrowth, dysbiosis, leaky bowel, bacterial translocation, and imbalanced metabolites are related to the progression of chronic liver disease. Recently, novel therapeutic approaches for microbiota modulation such as personalized diet, probiotics, prebiotics, antibiotics, engineered microbiotas, phage therapy, stomach operation, and fecal microbiota transplantation (FMT) have been proposed with numerous promising results in the effectiveness and clinical application. Although the evidence is still lacking, FMT, a type of fecal bacteriotherapy, has been known as a candidate for the treatment of liver disease. This review article focuses on the most recent advances in our understanding of FMT in chronic liver disease such as non\u2010alcoholic and alcohol\u2010related liver disease.<\/jats:p>","DOI":"10.1111\/jgh.15729","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T02:56:26Z","timestamp":1635994586000},"page":"24-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["New perspective on fecal microbiota transplantation in liver diseases"],"prefix":"10.1111","volume":"37","author":[{"given":"Ki Tae","family":"Suk","sequence":"first","affiliation":[{"name":"Institute for Liver and Digestive Diseases Hallym University  Chuncheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-7483","authenticated-orcid":false,"given":"Hong","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Severance Fecal Microbiota Transplantation Center, Severance Hospital Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0159-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126326"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1593882"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf3363"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.067"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505036"},{"key":"e_1_2_11_9_1","first-page":"420","article-title":"Fecal microbiota transplantation: past, present and future perspectives","volume":"63","author":"Bibb\u00f2 S","year":"2017","journal-title":"Minerva Gastroenterol. 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