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The incidence of MAFLD has been reported to be 43\u201360% in diabetics, ~90% in patients with hyperlipidemia, and 91% in morbidly obese patients. Risk factors that have been associated with the development of MAFLD include male gender, increasing age, obesity, insulin resistance, diabetes, and hyperlipidemia. All of these risk factors have been linked to alterations of the gut microbiota, that is, gut dysbiosis. MAFLD can progress to non\u2010alcoholic steatohepatitis with the presence of inflammation and ballooning, which can deteriorate into cirrhosis, MAFLD\u2010related hepatocellular carcinoma, and liver failure. In this review, we will be focused on the role of the gut microbial metabolome in the development, progression, and potential treatment of MAFLD.<\/jats:p>","DOI":"10.1111\/jgh.15746","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T03:05:47Z","timestamp":1638327947000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The microbial metabolome in metabolic\u2010associated fatty liver disease"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-2232","authenticated-orcid":false,"given":"Mengci","family":"Li","sequence":"first","affiliation":[{"name":"Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Jiao Tong University Affiliated Sixth People's Hospital  Shanghai 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