{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:31:05Z","timestamp":1747186265019,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The study was undertaken in order to compare single injection indocyanine green (ICG)\u2010clearances with the steady\u2010state ICG\u2010clearance (ICG<jats:sub>Cl<\/jats:sub>) in patients with cirrhosis in order to assess the most accurate estimate for ICG\u2010clearance and to relate the ICG\u2010clearances to established indicators of liver dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight patients (male 29) with cirrhosis (Child\u2013Turcotte class A 8, class B 21, and class C 9) were studied during a hemodynamic investigation. A single injection of ICG was followed by blood samples for 5, 10, 15, and 20\u00a0min. The dose\/plasma area clearance (Cl<jats:sub>A<\/jats:sub>) and plasma volume\u00a0\u00b7\u00a0initial slope clearance (Cl<jats:sub>PV<\/jats:sub>) were determined and compared with the steady\u2010state infusion\/plasma concentration ratio clearance (ICG<jats:sub>Cl<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Cl<jats:sub>A<\/jats:sub> (310; 214; 502\u00a0mL\/min) and Cl<jats:sub>PV<\/jats:sub> (294; 164; 481\u00a0mL\/min) correlated closely with ICG<jats:sub>Cl<\/jats:sub> (243; 120; 383\u00a0mL\/min [median; interquartile range], <jats:italic>R<\/jats:italic>\u00a0=\u00a00.95\u20130.98, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.000), but were significantly higher than ICG<jats:sub>Cl<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). All three clearance measures correlated significantly with biochemical and hemodynamic variables of liver dysfunction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05\u20130.000). All three ICG\u2010clearances showed significantly lower values in patients with ascites compared to those without, and lower ICG\u2010clearance values were present in patients with esophageal varices compared to those without (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05\u20130.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Single injection markers (Cl<jats:sub>A<\/jats:sub> and Cl<jats:sub>PV<\/jats:sub>) of the steady\u2010state ICG\u2010clearance as derived from the ICG\u2010retention curve and the plasma volume correlate with ICG<jats:sub>Cl<\/jats:sub> and established variables of portal hypertension and liver cell bile excretory dysfunction. Therefore, these markers can safely replace the more costly ICG<jats:sub>Cl<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15778","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T23:02:40Z","timestamp":1641942160000},"page":"692-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-7764","authenticated-orcid":false,"given":"S\u00f8ren","family":"M\u00f8ller","sequence":"first","affiliation":[{"name":"Center of Functional and Diagnostic Imaging and Research, Department of Clinical Physiology and Nuclear Medicine 260 Copenhagen University Hospital Hvidovre  Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences Copenhagen University  Copenhagen 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