{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:01:00Z","timestamp":1792555260281,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>There is limited data on the rate of new or recurrent cancer in patients with inflammatory bowel disease (IBD) and a history of prior or current malignancy who are initiated on biologic therapies. Furthermore, there is no data on this topic in patients using ustekinumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The retrospective study included 341 patients with IBD and a history of cancer who were subsequently treated with vedolizumab (VDZ; <jats:italic>n<\/jats:italic>\u00a0=\u00a034), ustekinumab (USK; <jats:italic>n<\/jats:italic>\u00a0=\u00a027), tumor necrosis factor \u03b1 antagonists (anti\u2010TNF; <jats:italic>n<\/jats:italic>\u00a0=\u00a099), or had no immunosuppressive therapy (control; <jats:italic>n<\/jats:italic>\u00a0=\u00a0181). Cox proportional hazard models were developed to determine the independent effect of post\u2010cancer immunosuppressive treatment on the occurrence of incident cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median of 5.2 person\u2010years of follow up, cancer recurrence occurred in only one patient on anti\u2010TNF, while new cancers developed in one patient on VDZ, three patients on USK, and six patients on anti\u2010TNF, corresponding to cancer rates of 0.4, 1.8, and 0.7 per 100 person\u2010years, respectively. The rate of incident cancer in control patients was 2.4 per 100 person\u2010years and included 18 new and 9 recurrent cancers. Compared with controls, a stepwise Cox proportional hazards model adjusting for significant covariates found no increased risk of incident cancer in patients receiving post\u2010malignancy treatment with USK (hazard ratio [HR] 0.88; 95% confidence interval [CI] 0.25\u20133.03), VDZ (HR 0.18; 95% CI 0.03\u20131.35), or anti\u2010TNF (HR 0.47; 95% CI 0.20\u20131.12).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of biologic therapy in IBD patients with a previous history of malignancy was not associated with an increased risk of new or recurrent cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15806","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T03:58:28Z","timestamp":1645502308000},"page":"1016-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ustekinumab does not increase risk of new or recurrent cancer in inflammatory bowel disease patients with prior malignancy"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3813-5405","authenticated-orcid":false,"given":"Badar","family":"Hasan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanwarpreet Singh","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Miret","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikandar","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Riaz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalberto","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-8436","authenticated-orcid":false,"given":"Neeraj","family":"Narula","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine and Farncombe Family Digestive Health Research Institute McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando J.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cleveland Clinic Florida  Weston Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109263251306"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04330.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61302-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000211"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy313"},{"key":"e_1_2_6_7_1","article-title":"Vedolizumab or tumor necrosis factor antagonist use and risk of new or recurrent cancer in patients with inflammatory bowel disease with prior malignancy: a retrospective cohort study","author":"Vedamurthy A","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol. [Internet]"},{"key":"e_1_2_6_8_1","article-title":"Risk of new or recurrent cancer in patients with inflammatory bowel disease and previous cancer exposed to immunosuppressive and anti\u2010tumor necrosis factor agents","volume":"14","author":"Axelrad J","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol. [Internet]"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305763"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010199304000\u201000011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532694"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i30.4158"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv059"},{"key":"e_1_2_6_15_1","unstructured":"CDC.Data and statistics [Internet].2020. Cited 24 May 2021. Available from URL:https:\/\/www.cdc.gov\/ibd\/data\u2010statistics.htm"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000191"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12624"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30362-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.07.013"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz110"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1900750"},{"key":"e_1_2_6_22_1","unstructured":"Admin S.P729 The SAPPHIRE registry: safety of immunosuppression in a prospective cohort of inflammatory bowel disease patients with a HIstoRy of CancEr [Internet]. Cited 26 Sep 2021. 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