{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T21:20:36Z","timestamp":1782681636310,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To clarify the clinicoepidemiological characteristics of immunoglobulin G4 (IgG4)\u2010related disease (IgG4\u2010RD) with malignancy, a nationwide epidemiological survey was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunoglobulin G4\u2010related disease patients with malignancy who had visited selected hospitals in Japan were surveyed. The study consisted of two stages: the number of IgG4\u2010RD patients with malignancy was estimated by the first questionnaire and their clinicoepidemiological characteristics were assessed by the second questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequencies of autoimmune pancreatitis (AIP), IgG4\u2010related sialadenitis, IgG4\u2010related eye disease, IgG4\u2010related kidney disease, and IgG4\u2010related retroperitoneal fibrosis were 44.7%, 20.8%, 14.0%, 5.16%, and 5.12%, respectively. The overall prevalence of malignant disease in IgG4\u2010RD cases was estimated to be 10\u00a0900 per 100\u00a0000 cases, which was significantly higher than that of malignant disease in the general population. The prevalence of malignant lymphoma in IgG4\u2010RD cases was the highest and was estimated to be 1985 per 100\u00a0000 cases. IgG4\u2010related kidney disease had the highest frequency of malignant disease (17.1%). In data from 200 patients, 61 (30.5%) cases of cancer were found 2\u00a0years or more before the IgG4\u2010RD diagnosis, 92 cases (46%) during the 1\u00a0year preceding or following IgG4\u2010RD diagnosis, and 62 cases of cancer (31%) 2 or more years following IgG4\u2010RD diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nationwide survey for IgG4\u2010RD with malignancy in Japan showed that IgG4\u2010RD may be related with malignant diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15809","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T04:34:18Z","timestamp":1646109258000},"page":"1022-1033","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Nationwide epidemiological survey of immunoglobulin G4\u2010related disease with malignancy in Japan"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-8279","authenticated-orcid":false,"given":"Kimi","family":"Sumimoto","sequence":"first","affiliation":[{"name":"The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology Kansai Medical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Kochi Medical School Kochi University  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Ikeura","sequence":"additional","affiliation":[{"name":"The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology Kansai Medical University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of 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