{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:43:59Z","timestamp":1792226639140,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This systematic review was aimed to estimate hepatitis C virus (HCV) seroprevalence and burden in disease in WHO South East Asia Region (SEAR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic databases (PubMed, Scopus, Embase, and Google Scholar) and websites of non\u2010indexed national medical journals, government and international health agencies were searched to identify English language literature published between 1991 and June 2020. We selected the studies reporting HCV seroprevalence in asymptomatic general (low\u2010risk) and high\u2010risk adult populations, that is, persons living with HIV (PLHIV), persons who inject drugs (PWID), sex workers, persons on maintenance hemodialysis (MHD), people in prison, and men sex with men (MSM). Seroprevalence data were combined to estimate weighted pooled prevalence (95% confidence interval) in each group and in each country, using the random\u2010effects model. Estimated pooled seroprevalences were multiplied with estimated populations at risk to estimate the overall HCV burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 538 studies (35 Bangladesh, 6 Bhutan, 2 DPR Korea, 323 India, 43 Indonesia, 2 Maldives, 18 Myanmar, 29 Nepal, 11 Sri Lanka, 67 Thailand, and 2 Timor\u2010Leste). In SEAR, the weighted pooled anti\u2010HCV seroprevalence was estimated as 0.84% (0.56\u20131.12) in low\u2010risk population and 13.67% (10.95\u201316.40) in PLHIV, 51.44% (43.67\u201359.20) in PWID, 25.80% (20.34\u201332.09) in MHD, 8.39% (5.84\u201311.51) in prison inmates, 2.69% (1.43\u20134.13) in people with high\u2010risk sex behavior, and 11.43% (8.61\u201314.74) in MSM. The total HCV burden in low\u2010risk and high\u2010risk populations in SEAR countries was estimated as 12.45 million and 1.65 million, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our estimates of HCV seroprevalence and burden should help the respective countries in planning their HCV elimination strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15827","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T23:54:18Z","timestamp":1646870058000},"page":"964-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Seroprevalence and burden of hepatitis C virus infection in WHO South\u2010East Asia Region: A systematic review"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-9381","authenticated-orcid":false,"given":"Amit","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat Bhushan","family":"Rewari","sequence":"additional","affiliation":[{"name":"World Health Organization, Regional Office for South\u2010East Asia  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukta","family":"Sharma","sequence":"additional","affiliation":[{"name":"World Health Organization, Regional Office for South\u2010East Asia  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel Mangadan","family":"Konath","sequence":"additional","affiliation":[{"name":"World Health Organization, Regional Office for South\u2010East Asia  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-494X","authenticated-orcid":false,"given":"Rakesh","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Postgraduate Medical Education and Research  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Global Health Estimates 2019: Deaths by Cause Age Sex by Country and by Region 2000\u20102019. 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