{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:31Z","timestamp":1787015551008,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"Abstract<\/jats:title>\n \n Background and Aim<\/jats:title>\n \n Rates of antimicrobial\u2010resistant\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n infection are rising globally; however, geospatial location and its interaction with risk factors for infection have not been closely examined.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Gastric biopsy specimens were collected to detect\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n infection at multiple centers in Adelaide, South Australia, between 1998 and 2017. The geospatial distribution of antibiotic\u2010resistant\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n in the Greater Adelaide region was plotted using choropleth maps. Moran's\n I<\/jats:italic>\n was used to assess geospatial correlation, and multivariate linear regression (MLR) was used to examine associations between migration status, socioeconomic status, age, gender, and rates of\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n positivity and antibiotic resistance. Geographically weighted regression (GWR) was used to determine the extent to which the associations varied according to geospatial location.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 20\u00a0108 biopsies across 136 postcodes within the Greater Adelaide region, 1901 (9.45%) were\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n positive. Of these, 797 (41.9%) displayed clarithromycin, tetracycline, metronidazole, or amoxicillin resistance. In MLR, migration status was associated with the rate of\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n positivity (\n \u03b2<\/jats:italic>\n \u00a0=\u00a03.85% per 10% increase in a postcode's migrant population;\n P<\/jats:italic>\n \u00a0<\u00a00.001).\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n positivity and resistance to any antibiotic were geospatially clustered (Moran's\n I<\/jats:italic>\n \u00a0=\u00a00.571 and 0.280, respectively;\n P<\/jats:italic>\n \u00a0<\u00a00.001 for both). In GWR, there was significant geospatial variation in the strength of the migrant association for both\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n positivity and antibiotic resistance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our study demonstrates the heterogeneous geospatial distribution of\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n positivity and antibiotic resistance, as well as its interaction with migrant status. Geographic location and migrant status are important factors to consider for\n \n H.\u00a0pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.15832","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T21:19:32Z","timestamp":1647897572000},"page":"1263-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Geospatial analysis of\n \n Helicobacter pylori<\/i>\n <\/scp>\n infection in South Australia: Should location influence eradication therapy?"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7201-1188","authenticated-orcid":false,"given":"Jonathon P","family":"Schubert","sequence":"first","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Woodman","sequence":"additional","affiliation":[{"name":"Flinders Centre for Epidemiology and Biostatistics Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arduino A","family":"Mangoni","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Flinders Medical Centre Flinders University Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K","family":"Rayner","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Department of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgyn S","family":"Warner","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Microbiology and Infectious Diseases Directorate SA Pathology Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian C","family":"Roberts\u2010Thomson","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel P","family":"Costello","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V","family":"Bryant","sequence":"additional","affiliation":[{"name":"Adelaide Medical School, Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia"},{"name":"Department of Gastroenterology The Queen Elizabeth Hospital Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.24.012902.141019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr384"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"e_1_2_7_5_1","first-page":"414","article-title":"A systematic review and meta\u2010analysis of the role of Helicobacter pylori eradication in preventing gastric cancer","volume":"30","author":"Rokkas T","year":"2017","journal-title":"Ann. 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