{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:11:20Z","timestamp":1791821480159,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Although patients report either improved or worsened halitosis after <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> eradication therapy, such complaints are subjective. Only a few studies have objectively evaluated reports of changes in halitosis after <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication; thus, this study aimed to investigate these changes after a successful <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between February 2015 and October 2018, 56\u00a0347 patients visited the clinic. Informed consent for participation in this study was obtained from 164 patients scheduled to undergo upper gastrointestinal endoscopy due to halitosis. Of the 91 patients with <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> infection, the halitosis values were evaluated as Refres breath (RB) values using a Total Gas Detector\u2122 System and compared before and after successful <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication, as confirmed with urea breath testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 91 patients treated, 77 patients were successfully eradicated of <jats:italic>H.\u00a0pylori<\/jats:italic> and had their Refres values measured (21 men and 56 women; mean age, 64.2\u00a0\u00b1\u00a011.5\u00a0years, including 10 smokers); among these 77 patients, 27 showed RB values of &gt;\u00a060. Their RB values significantly improved from 73.5\u00a0\u00c2 (95% confidence interval [CI], 64.1\u201382.9) to 59.4\u00a0\u00c2 (95% CI, 50.0\u201368.8) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.038). Of the 30 patients who could be followed up for &gt;\u00a02\u00a0years after successful <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication, 8 with an RB value\u00a0\u2265\u00a060 showed significant RB value improvements from 77.9\u00a0\u00c2 (95% CI, 59.4\u201396.4) to 30.1\u00a0\u00c2 (95% CI, 11.6\u201348.6) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0016).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content> eradication therapy could improve halitosis, and such improvement could be maintained even 2\u00a0years after successful eradication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15835","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:23:04Z","timestamp":1648167784000},"page":"928-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in halitosis value before and after <scp><i>Helicobacter pylori<\/i><\/scp> eradication: A single\u2010institutional prospective study"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5194-6574","authenticated-orcid":false,"given":"Yui","family":"Kudo","sequence":"first","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital  Yokohama Japan"},{"name":"Department of Gastroenterology Kudo Clinic  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-1217","authenticated-orcid":false,"given":"Shin\u2010ei","family":"Kudo","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-0899","authenticated-orcid":false,"given":"Hideyuki","family":"Miyachi","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-1219","authenticated-orcid":false,"given":"Katsuro","family":"Ichimasa","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9663-247X","authenticated-orcid":false,"given":"Yuta","family":"Kouyama","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kudo Clinic  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kudo Clinic  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kudo Clinic  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6904-6777","authenticated-orcid":false,"given":"Takuji","family":"Gotoda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05371"},{"key":"e_1_2_7_3_1","unstructured":"Ministry of Health.Labour and welfare. 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