{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:19:24Z","timestamp":1781551164437,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Duodenal ulcers, especially caused by increasingly drug\u2010resistant <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter pylori<\/jats:italic><\/jats:styled-content>, are a concern in Asia. We compared oral vonoprazan <jats:italic>versus<\/jats:italic> lansoprazole for efficacy (healing duodenal ulcers) and safety in non\u2010Japanese Asian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this phase 3, randomized (1:1), double\u2010blind, double\u2010dummy, parallel\u2010group, non\u2010inferiority study (April 5, 2017, to July 19, 2019), patients with \u2265\u00a01 endoscopically confirmed duodenal ulcer, at 52 hospitals (China, South Korea, and Taiwan), received vonoprazan 20\u00a0mg once daily (QD) or lansoprazole 30\u00a0mg QD for 6\u00a0weeks maximum. Patients with <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> received bismuth\u2010containing quadruple therapy including vonoprazan 20\u00a0mg twice daily (BID) or lansoprazole 30\u00a0mg BID, for 2\u00a0weeks, followed by vonoprazan or lansoprazole monotherapy QD (4\u00a0weeks maximum). Endpoints were endoscopically confirmed duodenal ulcer healing (Week 4\/6; primary) and <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication (4\u00a0weeks post\u2010treatment; secondary); non\u2010inferiority margins were \u22126% and \u221210%, using a two\u2010sided 95% confidence interval (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 533 enrolled patients, one was lost to follow\u2010up and one withdrew (full analysis set: 531 patients [vonoprazan, <jats:italic>n<\/jats:italic>\u00a0=\u00a0263; lansoprazole, <jats:italic>n<\/jats:italic>\u00a0=\u00a0268]; 85.4%\u00a0=\u00a0<jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> positive). Vonoprazan was non\u2010inferior to lansoprazole for duodenal ulcer healing (96.9% <jats:italic>vs<\/jats:italic> 96.5%; difference 0.4% [95% CI \u22123.00, 3.79]). <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication rates were 91.5% (vonoprazan) and 86.8% (lansoprazole; difference 4.7% [95% CI \u22121.28, 10.69]). Vonoprazan and lansoprazole were well tolerated, with similar safety profiles, no new safety signals; no deaths occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vonoprazan was well tolerated and non\u2010inferior to lansoprazole for duodenal ulcer healing and achieved <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u00a0pylori<\/jats:italic><\/jats:styled-content> eradication above the clinically meaningful threshold (90%), in non\u2010Japanese Asian patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15837","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T01:05:35Z","timestamp":1648429535000},"page":"1275-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Vonoprazan non\u2010inferior to lansoprazole in treating duodenal ulcer and eradicating <scp><i>Helicobacter pylori<\/i><\/scp> in Asian patients"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3694-2126","authenticated-orcid":false,"given":"Xiaohua","family":"Hou","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-575X","authenticated-orcid":false,"given":"Fandong","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbin","family":"Wang","sequence":"additional","affiliation":[{"name":"China\u2010Japan Union Hospital, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4180-5211","authenticated-orcid":false,"given":"Weihong","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)  Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Tang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital, Linkou Medical Center  Taoyuan Taiwan"},{"name":"Chang Gung University, College of Medicine  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Chul","family":"Chung","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital, College of Medicine, The Catholic University of Korea  Seoul South 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