{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:35:26Z","timestamp":1772832926304,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Amed\u2010Crest 20gm1010004h0205"],"award-info":[{"award-number":["Amed\u2010Crest 20gm1010004h0205"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04159"],"award-info":[{"award-number":["17H04159"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) induce intestinal enteropathy and the pathophysiology is related to immune\u2010mediated mechanisms. We aimed to investigate the role of C\u2010C chemokine receptor type 7 (CCR7) which regulates immune cell migration in NSAID\u2010induced enteropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Injury of the small intestine was evaluated 24\u00a0h after the subcutaneous injection of indomethacin in CCR7\u2010deficient (<jats:italic>Ccr7<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup>) and wild\u2010type (WT) mice. The cellular profile and cytokine production in intestinal cells were analyzed. Indomethacin\u2010induced enteropathy was evaluated in mice adoptively transferred with CD103<jats:sup>+<\/jats:sup> dendritic cells (DCs) from <jats:italic>Ccr7<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> or WT mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Indomethacin induced more severe intestinal injury in <jats:italic>Ccr7<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice than in WT mice. The major inflammatory cytokines were not increased and the proportion of regulatory T cells following indomethacin injection was not decreased in <jats:italic>Ccr7<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice compared with WT mice. The expression of interleukin (IL)\u201022 binding protein (IL\u201022BP), which inhibits IL\u201022 activity, was significantly higher in CD103<jats:sup>+<\/jats:sup> DCs from <jats:italic>Ccr7<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice than those from WT mice. Mice adoptively transferred with CD103<jats:sup>+<\/jats:sup> DCs isolated from <jats:italic>Ccr7<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice exhibited more severe intestinal injury following indomethacin injection compared with those adoptively transferred with CD103<jats:sup>+<\/jats:sup> DCs of WT mice. <jats:italic>Ccr7<\/jats:italic><jats:sup><jats:italic>\u2212\/\u2212<\/jats:italic><\/jats:sup> mice injected with indomethacin showed a significant reduction in regenerating islet\u2010derived 1 (<jats:italic>Reg1<\/jats:italic>) mRNA expression, which is regulated by IL\u201022, in intestinal epithelial cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>C\u2010C chemokine receptor type 7 deficiency exacerbated NSAID\u2010induced enteropathy in association with an altered phenotype of CD103<jats:sup>+<\/jats:sup> DCs that produces IL\u201022BP. CCR7 contributes to protect the small intestine from NSAID\u2010induced mucosal injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15868","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T13:38:37Z","timestamp":1650289117000},"page":"1561-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exacerbation of non\u2010steroidal anti\u2010inflammatory drug\u2010induced enteropathy in C\u2010C chemokine receptor type 7\u2010deficient mice"],"prefix":"10.1111","volume":"37","author":[{"given":"Toshio","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Osaka University Graduate School of Medicine  Osaka Japan"},{"name":"Department of Gastroenterology Osaka Rosai Hospital  Osaka 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