{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:31:17Z","timestamp":1747186277138,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To clarify whether there were any significant differences in clinical symptoms and eating patterns between functional dyspepsia (FD) patients and FD with pancreatic enzyme abnormalities (FD\u2010P) patients as refractory FD, we compared these factors in multicenter studies in Singapore and Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred ninety\u2010eight consecutive patients presenting with FD (<jats:italic>n<\/jats:italic>\u00a0=\u00a088), FD\u2010P patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a081) based on Rome III classification and controlled group (<jats:italic>n<\/jats:italic>\u00a0=\u00a039) recruited from six institutions in Singapore and Japan. Clinical characteristics, clinical symptoms for dietary fat intake, and eating behaviors were estimated using questionnaires. Anxiety and health\u2010related quality of life were determined by STAI\u2010state\/\u2010trait and SF\u20108, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in age, sex, BMI, smoking, alcohol intake, past medical history, and history of allergy in FD and FD\u2010P patients between Singapore and Japan. There were no significant differences in FD subtypes, gastrointestinal symptom rating scale score, severity of FD symptoms, and eating pattern in Singapore and Japan. Moreover, there were significant differences in certain eating behaviors between FD and FD\u2010P patients in Singapore and Japan. Interestingly, epigastric pain and early satiety following fat meals in FD\u2010P patients were significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008, respectively) higher compared with those in FD patients in Japan. Physical component score in FD\u2010P patients was significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019) disturbed compared with those in FD patients in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Epigastric pain and early satiety following fat meals in FD\u2010P patients may be useful tools to differentiate FD\u2010P patients from FD patients in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15874","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T02:24:02Z","timestamp":1651544642000},"page":"1525-1533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of clinical characteristics, eating behaviors, and clinical symptoms following fat intake in functional dyspepsia with functional dyspepsia with pancreatic enzyme abnormalities between Singapore and Japan"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-8646","authenticated-orcid":false,"given":"Seiji","family":"Futagami","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaomi","family":"Kessoku","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City Univeristy  Yokohama Japan"},{"name":"Department of Palliative Medicine Yokohama City University Hospital  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yokohama City Univeristy  Yokohama 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Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Habiro","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iori","family":"Sanada","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Kawasaki Rinko General Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamato","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatsugu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University  Tokyo 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