{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:22:57Z","timestamp":1789662177036,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>The portal pressure gradient (PPG) is a useful predictor of portal hypertension (PH) related complications. We previously showed the feasibility and safety of endoscopic ultrasound guided PPG measurement (EUS\u2010PPG). Now EUS\u2010guided liver biopsy (EUS\u2010bx) has been shown to be a safe and effective alternative to percutaneous or Interventional Radiology\u2010guided liver biopsy for the diagnosis of chronic liver disease (CLD). We aimed to evaluate the correlation between PPG and clinical markers of PH, and assess the feasibility and safety of concomitant, single session EUS\u2010PPG and EUS\u2010bx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of patients undergoing EUS\u2010PPG for CLD at a single tertiary endoscopy center between February 2014 and March 2020. EUS\u2010PPG was performed using a 25\u2010gauge needle and compact manometer. Data analysis was performed with SAS version 9.4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010three patients underwent EUS\u2010PPG with 100% technical success. The mean PPG was 7.06\u00a0mmHg (SD 6.09, range 0\u201327.3). PPG was higher in patients with (\n                      <jats:italic>vs<\/jats:italic>\n                      without) clinical features of cirrhosis (9.46\n                      <jats:italic>vs<\/jats:italic>\n                      3.61\u00a0mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), esophageal or gastric varices (13.88\n                      <jats:italic>vs<\/jats:italic>\n                      4.34\u00a0mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), and thrombocytopenia (9.25\n                      <jats:italic>vs<\/jats:italic>\n                      4.71\u00a0mmHg,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0022). In the 71 patients (85.5%) who underwent EUS\u2010bx, 70 (98.6%) specimens were deemed adequate by the pathologist for histologic diagnosis. There were no early or late major adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EUS\u2010PPG correlates well with clinical markers of PH. EUS\u2010bx can be performed safely during the same session as EUS\u2010PPG, providing a comprehensive endoscopic evaluation of the patient with CLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.15875","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T23:58:25Z","timestamp":1651795105000},"page":"1373-1379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Endoscopic ultrasound\u2010guided portal pressure gradient with liver biopsy: 6\u00a0years of endo\u2010hepatology in practice"],"prefix":"10.1111","volume":"37","author":[{"given":"Alyssa Y.","family":"Choi","sequence":"first","affiliation":[{"name":"H. H. Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kolb","sequence":"additional","affiliation":[{"name":"H. H. Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Shah","sequence":"additional","affiliation":[{"name":"Irvine Medical Center  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Chahine","sequence":"additional","affiliation":[{"name":"Irvine Medical Center  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintaro","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"H. H. Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Patel","sequence":"additional","affiliation":[{"name":"H. H. Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Tsujino","sequence":"additional","affiliation":[{"name":"H. H. Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Huang","sequence":"additional","affiliation":[{"name":"H. H. Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Qin","family":"Hu","sequence":"additional","affiliation":[{"name":"H. H. Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Chang","sequence":"additional","affiliation":[{"name":"H. H. 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Chao Comprehensive Digestive Disease Center University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1504367"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23478"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.01.014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250145"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.12.83"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026622721389"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.02.032"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.09.026"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.08.012"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.09.043"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.05.013"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22742"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.1999.01377.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000830"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/eus.eus_30_18"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.149"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20871"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.02.009"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2010.04484.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.09.023"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24830"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000897"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105107(03)02544\u20106"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100034\u20101390845"},{"key":"e_1_2_5_29_1","doi-asserted-by":"crossref","unstructured":"LeeWJ UradomoLT ZhangY TwaddellW DarwinP.Comparison of the Diagnostic Yield of EUS Needles for Liver Biopsy: Ex Vivo Study. 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