{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:39:23Z","timestamp":1768289963741,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW106\u2010TDU\u2010B\u2010211\u2010113002"],"award-info":[{"award-number":["MOHW106\u2010TDU\u2010B\u2010211\u2010113002"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW108\u2010TDU\u2010B\u2010211\u2010133002"],"award-info":[{"award-number":["MOHW108\u2010TDU\u2010B\u2010211\u2010133002"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The small endoscopic ultrasound (EUS)\u2010suspected gastric gastrointestinal stromal tumors (GISTs), gastric subepithelial tumors at the muscularis propria layer on EUS, are detected frequently. Bite\u2010on\u2010bite forceps biopsy and EUS\u2010guided tissue sampling yield variable results. This study aimed to analyze clinicopathologic features of the small EUS\u2010suspected gastric GISTs 2\u00a0cm or less in size and to evaluate the efficacy and safety of the endoscopic incisional biopsy (EIB) for these small tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study investigated 70 patients with small EUS\u2010suspected gastric GISTs 2\u00a0cm or less in size in two stages. Firstly, 30 patients were recruited for the efficacy and safety evaluation of the EIB. Secondly, 40 patients were randomly assigned to receive either EIB or the bite\u2010on\u2010bite biopsy for comparison of the diagnostic yield, procedure time, and adverse event rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Combining two study stages, leiomyoma (74%) was diagnosed histologically to outnumber GIST (26%) with a diagnostic rate of 94% for patients receiving EIB. <jats:italic>KIT<\/jats:italic> exon 11 mutations (50%) and <jats:italic>PDGFRA<\/jats:italic> exon 12 mutations (16%) were detected in the small gastric GISTs. In the direct comparison, the diagnostic yield of EIB and the bite\u2010on\u2010bite biopsy was 85% and 50%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.018). There was no statistically significant difference of the mean procedure time or adverse event rate between these two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Leiomyoma is more common than expected among these small tumors. Tissue diagnosis with an effective and safe sampling technique, such as EIB, is necessary for making further clinical decisions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.15876","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T05:14:27Z","timestamp":1651554867000},"page":"1588-1595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tissue diagnosis necessary for small endoscopic ultrasound\u2010suspected gastric gastrointestinal stromal tumors 2\u00a0cm or less in size: A prospective study focusing on the endoscopic incisional biopsy"],"prefix":"10.1111","volume":"37","author":[{"given":"Shenq\u2010Jie","family":"Wong","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Division of Gastroenterology, Department of Internal Medicine En Chu Kong Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Tung","family":"Shun","sequence":"additional","affiliation":[{"name":"Department of Pathology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Chuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Lun","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiann\u2010Hwa","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Division of Gastroenterology, Department of Internal Medicine Taipei Tzu\u2010Chi Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Tsui","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7370-5605","authenticated-orcid":false,"given":"Tsu\u2010Yao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Department of Laboratory Medicine National Taiwan University Cancer Center and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.040"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12854"},{"key":"e_1_2_5_4_1","series-title":"WHO classification of tumours series","volume-title":"Digestive System Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2019"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2009.43"},{"key":"e_1_2_5_6_1","unstructured":"National Comprehensive Cancer Network.Gastrointestinal stromal tumors (version 1.2021).https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/gist.pdf. 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